A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos
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DOI: 10.1002/jat.4093
Abstract: Aminoglycoside antibiotics are widely used for many life‐threatening infections. The use of aminoglycosides is often comprised by their deleterious side effects to the kidney and inner ear. A novel semisynthetic antibiotic, etimicin, has good antimicrobial… read more here.
Keywords: etimicin; hair cells; zebrafish embryos; ototoxicity ... See more keywords
Temporal bone histopathology of furosemide ototoxicity
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DOI: 10.1002/lio2.108
Abstract: To describe the human temporal bone pathology in two patients who incurred furosemide induced ototoxicity. read more here.
Keywords: bone histopathology; histopathology furosemide; temporal bone; histopathology ... See more keywords
Labyrinthine enhancement on 3D black blood MR images of the brain as an imaging biomarker for cisplatin ototoxicity in (lung) cancer patients
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DOI: 10.1007/s00234-020-02504-x
Abstract: Purpose Cancer patients treated with platinum-based chemotherapy can present with ototoxicity symptoms. The purpose of this work is to report the imaging features related to cisplatin ototoxicity. Methods Between December 2015 and March 2019, a… read more here.
Keywords: ototoxicity; cisplatin ototoxicity; cancer patients; labyrinthine enhancement ... See more keywords
2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose
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DOI: 10.1007/s12640-020-00252-7
Abstract: 2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing… read more here.
Keywords: ototoxicity; hydroxypropyl cyclodextrin; outer hair; loss ... See more keywords
Protective effect of gallic acid against cisplatin-induced ototoxicity in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Brazilian journal of otorhinolaryngology"
DOI: 10.1016/j.bjorl.2018.03.001
Abstract: INTRODUCTION Cisplatin is an antineoplastic agent widely used in the treatment of a variety of cancers. Ototoxicity is one of the main side-effects restricting the use of cisplatin. OBJECTIVE The purpose of this study was… read more here.
Keywords: gallic acid; cisplatin; ototoxicity; acid ... See more keywords
COAST (Cisplatin ototoxicity attenuated by aspirin trial): A phase II double-blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing-loss
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DOI: 10.1016/j.ejca.2017.09.033
Abstract: Background Cisplatin is one of the most ototoxic chemotherapy drugs, resulting in a permanent and irreversible hearing loss in up to 50% of patients. Cisplatin and gentamicin are thought to damage hearing through a common… read more here.
Keywords: ototoxicity; trial; hearing loss; cisplatin ... See more keywords
The protective role of tetramethylpyrazine against cisplatin-induced ototoxicity.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2017.01.005
Abstract: OBJECTIVES The aim of the present study was to investigate the protective effect of tetramethylpyrazine (TMP) on cisplatin-induced ototoxicity in rats. METHODS Forty healthy, female, 24-week-old, Sprague-Dawley rats (n = 40) were randomly assigned to four groups… read more here.
Keywords: cisplatin; group; induced ototoxicity; ototoxicity ... See more keywords
Evaluation of geranylgeranylacetone against cisplatin-induced ototoxicity by auditory brainstem response, heat shock proteins and oxidative levels in guinea pigs.
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2017.03.004
Abstract: This study aims to assess whether geranylgeranylacetone (GGA) could reduce ototoxicity induced by cisplatin through upregulation of not only heat shock protein(HSP)-70, but also HSP-27 and HSP-40, and to study if GGA would reduce cisplatin-induced… read more here.
Keywords: cisplatin; group; ototoxicity; heat shock ... See more keywords
Mechanisms of Ototoxicity and Otoprotection.
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DOI: 10.1016/j.otc.2021.08.007
Abstract: Ototoxicity refers to damage to the inner ear that leads to functional hearing loss or vestibular disorders by selected pharmacotherapeutics as well as a variety of environmental exposures (eg, lead, cadmium, solvents). This article reviews… read more here.
Keywords: ototoxicity; ototoxicity otoprotection; mechanisms ototoxicity;
Clinical Considerations for Routine Auditory and Vestibular Monitoring in Patients With Cystic Fibrosis.
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DOI: 10.1044/2021_aja-21-00031
Abstract: Purpose Specific classes of antibiotics, such as aminoglycosides, have well-established adverse events producing permanent hearing loss, tinnitus, and balance and/or vestibular problems (i.e., ototoxicity). Although these antibiotics are frequently used to treat pseudomonas and other… read more here.
Keywords: ototoxicity; patients cystic; ototoxicity management; cystic fibrosis ... See more keywords
A Randomized Controlled Trial Using Automated Technology for Improving Ototoxicity Monitoring in VA Oncology Patients.
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DOI: 10.1044/2021_aja-21-00032
Abstract: Purpose Determine the efficacy of ototoxicity monitoring (OM) administered as automated protocols with the Oto-ID mobile audiometer (automated ototoxicity monitoring [A-OM]), compared with usual care (UC) OM in cancer patients receiving cisplatin. Method Participants were… read more here.
Keywords: ototoxicity monitoring; audiology; ototoxicity; oncology ... See more keywords