The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.03.038
Abstract: The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and… read more here.
Keywords: otu amyloid; otu; upper hand; amyloid fibers ... See more keywords
Comparing DADA2 and OTU clustering approaches in studying the bacterial communities of atopic dermatitis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.001256
Abstract: Introduction The pathogenesis of atopic dermatitis (AD) is not yet fully understood, but the bacterial composition of AD patients’ skin has been shown to have an increased abundance of Staphylococcus aureus . More recently, coagulase-negative… read more here.
Keywords: staphylococcus; otu; bacterial communities; otu clustering ... See more keywords
Ranking the biases: The choice of OTUs vs. ASVs in 16S rRNA amplicon data analysis has stronger effects on diversity measures than rarefaction and OTU identity threshold
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0264443
Abstract: Advances in the analysis of amplicon sequence datasets have introduced a methodological shift in how research teams investigate microbial biodiversity, away from sequence identity-based clustering (producing Operational Taxonomic Units, OTUs) to denoising methods (producing amplicon… read more here.
Keywords: diversity; choice; otu; 16s rrna ... See more keywords
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201710
Abstract: The OTU deubiquitinase family is expanded in Toxoplasma parasites, and members show preferences for Lys6-, Lys11-, Lys48-, and Lys63-linked ubiquitin chains, and additional specificity for NEDD8. AlphaFold-guided structural analysis reveals cryptic ubiquitin-binding domains with functional… read more here.
Keywords: otu; apicomplexan parasites; characterisation; toxoplasma ... See more keywords