OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00839-3
Abstract: OTUB2 is a deubiquitinating enzyme that contributes to tumor progression. However, the expression of OTUB2 and its prognostic importance in gastric cancer remain unclear. The expression of OTUB2 and KRT80 in GC tissues was investigated… read more here.
Keywords: otub2 regulates; regulates krt80; otub2; proliferation ... See more keywords
Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-023-44466-7
Abstract: PD-L1 expression on the surface of cancer cells is believed to contribute to tumor immune evasion via triggering the inhibitory T cell co-receptor, PD-1, resulting in decreased T cell cytotoxicity. Here authors show that OTUB2… read more here.
Keywords: cancer; degradation; otub2; cell ... See more keywords
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Molecular Medicine"
DOI: 10.1038/s44321-025-00206-6
Abstract: As a common and severe cerebrovascular disease, ischemic stroke casts a significant shadow over global health. Unfortunately, the mechanisms regulating neuronal death in the affected areas remain largely unclear. Here, we found that deletion of… read more here.
Keywords: ischemic stroke; stroke; neuronal necroptosis; otub2 ... See more keywords