Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc.
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DOI: 10.1038/s41418-022-00960-x
Abstract: MYC drives the tumorigenesis of human cancers, including prostate cancer (PrCa), thus deubiquitinase (DUB) that maintains high level of c-Myc oncoprotein is a rational therapeutic target. Several ubiquitin-specific protease (USP) family members of DUB have… read more here.
Keywords: prostatic tumorigenesis; otud6a; prca; myc ... See more keywords
OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03133-1
Abstract: Ovarian tumor (OTU) subfamily deubiquitinases are involved in various cellular processes, such as inflammation, ferroptosis and tumorigenesis; however, their pathological roles in prostate cancer (PCa) remain largely unexplored. In this study, we observed that several… read more here.
Keywords: prostate tumorigenesis; otud6a; brg1; pca ... See more keywords