Upregulation of OTULIN Alleviated Recurrent Pregnancy Loss by Suppressing Trophoblast Dysfunction and NF‐κB Signaling Pathway
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DOI: 10.1002/mrd.70029
Abstract: Recurrent pregnancy loss (RPL) is one of obstetrical diseases with no effective therapy methods. Trophoblast cell dysfunction and inflammation induce embryo implantation insufficiency, thereby resulting in RPL. OTU deubiquitinase with linear linkage specificity (OTULIN) plays… read more here.
Keywords: otulin overexpression; otulin; recurrent pregnancy; pregnancy loss ... See more keywords
Reciprocal interplay between OTULIN–LUBAC determines genotoxic and inflammatory NF-κB signal responses
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123097119
Abstract: Significance Deubiquitinases have emerged as a new class of modulators governing nuclear factor-kappa B (NF-κB) signaling. Ovarian tumor family deubiquitinase OTULIN inhibits NF-κB activation via counteracting the linear ubiquitin chain assembly complex (LUBAC). Clinically, OTULIN… read more here.
Keywords: otulin; reciprocal interplay; genotoxic inflammatory; interplay otulin ... See more keywords
A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad002
Abstract: Abstract While linear ubiquitin plays critical roles in multiple cell signaling pathways, few substrates have been identified. Global profiling of linear ubiquitin substrates represents a significant challenge because of the low endogenous level of linear… read more here.
Keywords: bio orthogonal; otulin; linear ubiquitin; linear ubiquitination ... See more keywords