Reciprocal interplay between OTULIN–LUBAC determines genotoxic and inflammatory NF-κB signal responses
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123097119
Abstract: Significance Deubiquitinases have emerged as a new class of modulators governing nuclear factor-kappa B (NF-κB) signaling. Ovarian tumor family deubiquitinase OTULIN inhibits NF-κB activation via counteracting the linear ubiquitin chain assembly complex (LUBAC). Clinically, OTULIN… read more here.
Keywords: otulin; reciprocal interplay; genotoxic inflammatory; interplay otulin ... See more keywords
A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad002
Abstract: Abstract While linear ubiquitin plays critical roles in multiple cell signaling pathways, few substrates have been identified. Global profiling of linear ubiquitin substrates represents a significant challenge because of the low endogenous level of linear… read more here.
Keywords: bio orthogonal; otulin; linear ubiquitin; linear ubiquitination ... See more keywords