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   Articles with "ouabain" as a keyword



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Ouabain regulates kidney metabolic profiling in rat offspring of intrauterine growth restriction induced by low-protein diet.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.118281

Abstract: AIMS Intrauterine growth restriction (IUGR) can increase the risk of hypertension and kidney disease at adulthood due to fetal programming. In our previous study, we found that supplementation with low concentration of ouabain during pregnancy… read more here.

Keywords: growth restriction; ouabain; intrauterine growth; rat ... See more keywords
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Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania

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recommendations! Published in 2017 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2016.05.058

Abstract: Central infusion of the Na+/K+-ATPase inhibitor, ouabain in rats serves as an animal model of mania because it leads to hyperactivity, as well as reproduces ion dysregulation and reduced brain-derived neurotrophic factor (BDNF) levels similar… read more here.

Keywords: model mania; cognitive flexibility; ouabain; frontal cortex ... See more keywords
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Ouabain Does Not Induce Selective Spiral Ganglion Cell Degeneration in Guinea Pigs

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recommendations! Published in 2018 at "BioMed Research International"

DOI: 10.1155/2018/1568414

Abstract: Round window membrane (RWM) application of ouabain is known to selectively destroy type I spiral ganglion cells (SGCs) in cochleas of several rodent species, while leaving hair cells intact. This protocol has been used in… read more here.

Keywords: guinea; ouabain; spiral ganglion; sgc loss ... See more keywords
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Inhibition of Na+, K+ -ATPase with ouabain is detrimental to equine blastocysts

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recommendations! Published in 2020 at "Animal Reproduction"

DOI: 10.21451/1984-3143-ar2019-0079

Abstract: Abstract Although equine blastocysts ≤ 300 µm in diameter can be successfully vitrified, larger equine blastocysts are not good candidates for cryopreservation. As Na+, K+-ATPase is involved in maintaining blastocyst expansion, perhaps inhibition of this… read more here.

Keywords: inhibition atpase; ouabain; equine blastocysts;
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Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

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recommendations! Published in 2017 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2017.00895

Abstract: Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as… read more here.

Keywords: cardiotonic steroid; much cardiotonic; inflammation; ouabain ... See more keywords
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Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression

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recommendations! Published in 2020 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2020.01060

Abstract: Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+… read more here.

Keywords: death; atpase; ouabain; expression ... See more keywords
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Mesenchymal Stem/Stromal Cells in Three-Dimensional Cell Culture: Ion Homeostasis and Ouabain-Induced Apoptosis

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recommendations! Published in 2023 at "Biomedicines"

DOI: 10.3390/biomedicines11020301

Abstract: This study describes the changes in ion homeostasis of human endometrial mesenchymal stem/stromal cells (eMSCs) during the formation of three-dimensional (3D) cell structures (spheroids) and investigates the conditions for apoptosis induction in 3D eMSCs. Detached… read more here.

Keywords: ion homeostasis; cell; emscs; mesenchymal stem ... See more keywords
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Chronic Ouabain Prevents Radiation-Induced Reduction in the α2 Na,K-ATPase Function in the Rat Diaphragm Muscle

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231810921

Abstract: The damaging effect of ionizing radiation (IR) on skeletal muscle Na,K-ATPase is an open field of research. Considering a therapeutic potential of ouabain, a specific ligand of the Na,K-ATPase, we tested its ability to protect… read more here.

Keywords: rat diaphragm; muscle; atpase function; atpase ... See more keywords