Breaching bacterial biofilm with neutrophil α‐mannosidase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ce0419-139r
Abstract: In the current issue of Journal of Leukocyte Biology, Kugadas et al.1 examined a murine model of Pseudomonas aeruginosa infection of the cornea where the bacteria produce an exo-polysaccharide biofilm. These investigators demonstrated that outbred… read more here.
Keywords: c57bl mice; mice; outbred mice; biology ... See more keywords
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23649-0
Abstract: Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here,… read more here.
Keywords: diversity outbred; genetics; bmd; outbred mice ... See more keywords
Chronic Wound Infection Model of Acinetobacter baumannii in Outbred Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Military medicine"
DOI: 10.1093/milmed/usac020
Abstract: INTRODUCTION We established a murine wound infection model with doxycycline treatment against multidrug-resistant Acinetobacter baumannii (AB5075) in Institute of Cancer Research (ICR) outbred mice. METHODS Using three groups of neutropenic ICR mice, two full-thickness dorsal… read more here.
Keywords: outbred mice; acinetobacter baumannii; infection; wound infection ... See more keywords
High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains.
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsz278
Abstract: STUDY OBJECTIVES This study describes high-throughput phenotyping strategies for sleep and circadian behavior in mice, including examinations of robustness, reliability, and heritability among Diversity Outbred (DO) mice and their eight founder strains. METHODS We performed… read more here.
Keywords: founder; diversity outbred; founder strains; outbred mice ... See more keywords
Outbred Mice with Streptozotocin-Induced Diabetes Show Sex Differences in Glucose Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065210
Abstract: Outbred mice (ICR) with different genotypes and phenotypes have been reported to be more suitable for scientific testing than inbred mice because they are more similar to humans. To investigate whether the sex and genetic… read more here.
Keywords: outbred mice; glucose metabolism; sex; mice ... See more keywords