Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway‐Based Approach
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203984
Abstract: Mechanistic toxicology provides a powerful approach to inform on the safety of chemicals and the development of safe‐by‐design compounds. Although toxicogenomics supports mechanistic evaluation of chemical exposures, its implementation into the regulatory framework is hindered… read more here.
Keywords: outcome pathway; development new; development; chemical ... See more keywords
Development and analysis of an adverse outcome pathway network for human neurotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02551-1
Abstract: An adverse outcome pathway (AOP) network is an attempt to represent the complexity of systems toxicology. This study illustrates how an AOP network can be derived and analysed in terms of its topological features to… read more here.
Keywords: adverse outcome; network; outcome pathway; aop network ... See more keywords
Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.12.007
Abstract: The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or… read more here.
Keywords: adverse outcome; outcome pathway; mdma; developmental neurotoxicity ... See more keywords
COVID-19 and the liver: an adverse outcome pathway perspective
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152765
Abstract: Liver damage is observed in up to half of hospitalized COVID-19 patients and can result either from actions of SARS-CoV-2 as such or from pharmacological treatment. The present paper introduces an adverse outcome pathway construct… read more here.
Keywords: adverse outcome; covid liver; outcome pathway; pathway perspective ... See more keywords
Developing an adverse outcome pathway framework for carcinogenicity from alerts in an expert rule-based system
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology Letters"
DOI: 10.1016/j.toxlet.2018.06.813
Abstract: An alternative approach to organising this knowledge is the use of adverse outcome pathways (AOPs). An AOP is a mechanistic representation linking a molecular initiating event (MIE) to an adverse outcome (AO) through sequential key… read more here.
Keywords: adverse outcome; outcome; framework carcinogenicity; outcome pathway ... See more keywords
An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00396
Abstract: Nongenotoxic (NGTX) carcinogens induce cancer via other mechanisms than direct DNA damage. A recognized mode of action for NGTX carcinogens is induction of oxidative stress, a state in which the amount of oxidants in a… read more here.
Keywords: network; stress; outcome pathway; oxidative stress ... See more keywords
Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2021.1884314
Abstract: Abstract Background Decades of research to understand the impacts of various types of environmental occupational and medical stressors on human health have produced a vast amount of data across many scientific disciplines. Organizing these data… read more here.
Keywords: adverse outcome; risk; research; scientific disciplines ... See more keywords
Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2110312
Abstract: Abstract Background Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous insults, including ionizing radiation… read more here.
Keywords: outcome pathway; development; machine learning; radiation ... See more keywords
An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2020.1823934
Abstract: Abstract Small intestinal (SI) tumors are relatively uncommon outcomes in rodent cancer bioassays, and limited information regarding chemical-induced SI tumorigenesis has been reported in the published literature. Herein, we propose a cytotoxicity-mediated adverse outcome pathway… read more here.
Keywords: adverse outcome; small intestinal; captan folpet; outcome pathway ... See more keywords
Quantitative adverse outcome pathway (qAOP) using bayesian network model on comparative toxicity of multi-walled carbon nanotubes (MWCNTs): safe-by-design approach
Sign Up to like & getrecommendations! Published in 2022 at "Nanotoxicology"
DOI: 10.1080/17435390.2022.2140615
Abstract: Abstract While the various physicochemical properties of engineered nanomaterials influence their toxicities, their understanding is still incomplete. A predictive framework is required to develop safe nanomaterials, and a Bayesian network (BN) model based on adverse… read more here.
Keywords: network model; outcome pathway; model; adverse outcome ... See more keywords
A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx252
Abstract: Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and informatics-tool supported pipeline schemas for fitting such data into Adverse Outcome Pathway (AOP) descriptions could potentially… read more here.
Keywords: adverse outcome; pipeline; pathway descriptions; outcome pathway ... See more keywords