Adverse Outcome Pathways and the Paradox of Complex Simplicity
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5205
Abstract: An adverse outcome pathway (AOP) is a description of the sequence of causally linked events, spanning multiple levels of biological organization, required to produce a toxic effect when an organism is exposed to a stressor… read more here.
Keywords: adverse outcome; pathways paradox; outcome; aop framework ... See more keywords
Non-Animal Strategies for Toxicity Assessment of Nanoscale Materials: Role of Adverse Outcome Pathways in the Selection of Endpoints.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202007628
Abstract: Faster, cheaper, sensitive, and mechanisms-based animal alternatives are needed to address the safety assessment needs of the growing number of nanomaterials (NM) and their sophisticated property variants. Specifically, strategies that help identify and prioritize alternative… read more here.
Keywords: adverse outcome; outcome pathways; animal strategies; non animal ... See more keywords
The future trajectory of adverse outcome pathways: a commentary
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2183-2
Abstract: The advent of adverse outcome pathways (AOPs) has provided a new lexicon for description of mechanistic toxicology, and a renewed enthusiasm for exploring modes of action resulting in adverse health and environmental effects. In addition,… read more here.
Keywords: future trajectory; adverse outcome; outcome pathways; toxicology ... See more keywords
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity - A case study with aromatase inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2022.01.004
Abstract: The development and application of (quantitative) structure-activity relationship ((Q)SAR) models for reproductive toxicology remains challenging, given the complexity of the endpoint and the risks associated with subsequent decision making. Adverse outcome pathways (AOPs) organise knowledge… read more here.
Keywords: aromatase inhibition; adverse outcome; toxicology; outcome pathways ... See more keywords
Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny – part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?
Sign Up to like & getrecommendations! Published in 2021 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2021.1910625
Abstract: Abstract The current understanding of thyroid-related adverse outcome pathways (AOPs) with adverse neurodevelopmental outcomes in mammals has been reviewed. This served to establish if standard rodent toxicity test methods and in vitro assays allow identifying… read more here.
Keywords: adverse outcome; outcome pathways; thyroid hormone; thyroid ... See more keywords
162 Keynote: Adverse Outcome Pathways – a Framework for Designing Novel Approach Methods for Safety Assessment
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Work Exposures and Health"
DOI: 10.1093/annweh/wxac087.100
Abstract: The fast evolving technologies, the search for new chemicals and synthesis of substitutes for the existing chemicals, are posing unprecedented challenges on regulatory agencies that have mainly relied on toxicity testing in laboratory animals to… read more here.
Keywords: 162 keynote; safety; outcome pathways; adverse outcome ... See more keywords
AOP4EUpest: mapping of pesticides in adverse outcome pathways using a text mining tool
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa545
Abstract: Abstract Motivation Exposure to pesticides may lead to adverse health effects in human populations, in particular vulnerable groups. The main long-term health concerns are neurodevelopmental disorders, carcinogenicity as well as endocrine disruption possibly leading to… read more here.
Keywords: adverse outcome; outcome pathways; tool; mapping pesticides ... See more keywords