Clinical Outcomes after Clozapine Discontinuation in Patients with Schizophrenia: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacopsychiatry"
DOI: 10.1055/a-1811-7318
Abstract: INTRODUCTION Clozapine is the gold standard of treatment for patients with treatment-resistant schizophrenia. However, approximately 60% of those patients do not respond to clozapine; moreover, clinical outcomes after clozapine discontinuation are unclear so far. Therefore,… read more here.
Keywords: clinical outcomes; systematic review; clozapine discontinuation; outcomes clozapine ... See more keywords
According to the WHO clozapine pharmacovigilance database, the United Kingdom accounts for 968 fatal outcomes versus 892 in the rest of the world
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15522
Abstract: National drug agencies send reports of adverse drug reactions (ADRs) to the World Health Organization's (WHO) pharmacovigilance database, used by Montastruc et al. for an extremely important contribution regarding fatal outcomes of clozapine ADRs. The… read more here.
Keywords: fatal outcomes; database; clozapine patients; 968 fatal ... See more keywords
A retrospective analysis of cardiovascular outcomes of clozapine treated individuals within Hunter New England
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DOI: 10.1111/imj.16617
Abstract: Clozapine has demonstrated superiority in improving both positive and negative symptoms of treatment‐resistant schizophrenia; however, there are associated treatment‐limiting side effects, including myocarditis, cardiomyopathy and agranulocytosis. read more here.
Keywords: analysis cardiovascular; retrospective analysis; outcomes clozapine; cardiovascular outcomes ... See more keywords