Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos
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DOI: 10.1038/s41598-020-71412-0
Abstract: CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even… read more here.
Keywords: editing outcomes; crispr cas9; outcomes xenopus; penetrance ... See more keywords