2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity Research"
DOI: 10.1007/s12640-020-00252-7
Abstract: 2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing… read more here.
Keywords: ototoxicity; hydroxypropyl cyclodextrin; outer hair; loss ... See more keywords
Outer hair cell functioning in infants with iron deficiency anemia.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2020.110393
Abstract: BACKGROUND Distortion product otoacoustic emissions (DPOAE) in infants with Iron Deficiency Anemia (IDA) helps in understanding the cochlear status especially the functioning of outer hair cells. OBJECTIVES To analyze the presence of DPOAE across frequencies… read more here.
Keywords: outer hair; hair cell; iron deficiency; cell functioning ... See more keywords
Double fluorescent labelling of a bipolar epithelial cell in vitro: The outer hair cell
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2017.10.014
Abstract: BACKGROUND Fluorescence membrane markers are efficient tools for visualizing the dynamics of membrane recycling processes in living cells. The outer hair cell (OHC) - a bipolar epithelial cell in the cochlea - possesses endocytic activity… read more here.
Keywords: apical basal; bipolar epithelial; outer hair; epithelial cell ... See more keywords
Transcriptomes of cochlear inner and outer hair cells from adult mice
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DOI: 10.1038/sdata.2018.199
Abstract: Inner hair cells (IHCs) and outer hair cells (OHCs) are the two anatomically and functionally distinct types of mechanosensitive receptor cells in the mammalian cochlea. The molecular mechanisms defining their morphological and functional specializations are… read more here.
Keywords: outer hair; hair cells; ihcs ohcs; transcriptomes cochlear ... See more keywords
The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring
Sign Up to like & getrecommendations! Published in 2022 at "International Archives of Otorhinolaryngology"
DOI: 10.1055/s-0042-1745856
Abstract: Introduction Perinatal hypothyroidism has a negative repercussion on the development and maturation of auditory system function. However, its long-term effect on auditory function remains unsettled. Objective To evaluate the effect of prenatal hypothyroidism on the… read more here.
Keywords: function; induction hypothyroidism; outer hair; hypothyroidism ... See more keywords
Reliability of Serological Prestin Levels in Humans and its Relation to Otoacoustic Emissions, a Functional Measure of Outer Hair Cells
Sign Up to like & getrecommendations! Published in 2021 at "Ear and Hearing"
DOI: 10.1097/aud.0000000000001026
Abstract: Objectives: Serological biomarkers, common to many areas of medicine, have the potential to inform on the health of the human body and to give early warning of risk of compromised function or illness before symptoms… read more here.
Keywords: prestin; serum prestin; outer hair; hair cells ... See more keywords
Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2022.0139
Abstract: Outer hair cells are the cellular motors in the mammalian inner ear responsible for sensitive high-frequency hearing. Motor function over the frequency range of human hearing requires expression of the protein prestin in the OHC… read more here.
Keywords: cell; power output; frequency; power ... See more keywords
Opioid receptor activation modulates the calcium current in the cochlear outer hair cells of the rat
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15682
Abstract: Previous works showed that opioid peptides are produced by olivocochlear efferent neurons, while cochlear hair cells express opioid receptors. It has been proposed that opioids protect the auditory system from damage by intense stimulation, although… read more here.
Keywords: opioid receptor; hair cells; receptor; receptor activation ... See more keywords
A non-traditional interpretation of cochlear mechanics of the auditory system
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Acoustical Society of America"
DOI: 10.1121/1.4988755
Abstract: Cochlear mechanics is known to be energized by motility of outer hair cells. This study explored significance of diametric changes of outer hair cells that is usually neglected in cochlear mechanics. Several different mathematical models… read more here.
Keywords: outer hair; hair cells; non traditional; cochlear mechanics ... See more keywords
The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00501.2021
Abstract: The mammalian cochlea contains three rows of outer hair cells (OHCs) that amplify the basilar membrane traveling wave with high gain and exquisite tuning. The pattern of OHC loss caused by typical methods of producing… read more here.
Keywords: deiters cells; hair cells; amplification; row ... See more keywords
Two passive mechanical conditions modulate power generation by the outer hair cells
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DOI: 10.1371/journal.pcbi.1005701
Abstract: In the mammalian cochlea, small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback of the outer hair cells. The level of amplification is greater in the base than in the apex… read more here.
Keywords: outer hair; hair cells; organ corti; mechanical conditions ... See more keywords