Cleavage of the outer membrane protein OmpX by protealysin regulates Serratia proteamaculans invasion
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DOI: 10.1002/1873-3468.13897
Abstract: Protealysin is a thermolysin‐like protease of Serratia proteamaculans capable of specifically cleaving actin, which correlates with the invasive activity of these bacteria. Here, we show that inactivation of the protealysin gene does not inhibit invasion… read more here.
Keywords: serratia proteamaculans; protein ompx; protealysin; outer membrane ... See more keywords
Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202103442
Abstract: The efficacy of conventional antibiotics therapeutics has declined rapidly due to the emerged antibiotic resistance. There is an urgent need to develop novel approaches to address the problem of antibiotic shortage, particularly for Gram‐negative bacteria.… read more here.
Keywords: msn omv; rifampicin; outer membrane; gram ... See more keywords
Rapid surface display of mRNA antigens by bacteria-derived outer membrane vesicles for a personalized tumor vaccine.
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DOI: 10.1002/adma.202109984
Abstract: Therapeutic mRNA vaccination is an attractive approach to trigger antitumor immunity. However, the mRNA delivery technology for customized tumor vaccine is still limited. Herein, we employed bacteria-derived outer membrane vesicles (OMVs) as an mRNA delivery… read more here.
Keywords: tumor; bacteria derived; tumor vaccine; derived outer ... See more keywords
Biomimetic Lipopolysaccharide-Free Bacterial Outer Membrane-Functionalized Nanoparticles for Brain-Targeted Drug Delivery.
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DOI: 10.1002/advs.202105854
Abstract: The blood-brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC-K1) binding to and invasion of BBB endothelial cells… read more here.
Keywords: bacterial outer; membrane; brain targeted; outer membrane ... See more keywords
Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy
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DOI: 10.1002/advs.202417712
Abstract: This study presents an innovative approach utilizing a biocompatible shell to shield bacterial outer membrane vesicles (OMVs) and incorporate Fe ions and ultrasmall Au nanoparticles to develop a combined tumor therapeutic strategy. These chimeric nanozyme… read more here.
Keywords: outer membrane; tumor microenvironment; bacterial outer; membrane vesicles ... See more keywords
BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis
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DOI: 10.1002/advs.202504101
Abstract: Trained immunity, an innate immune memory, has emerged as a promising strategy to enhance host defense against sepsis, a leading cause of mortality in critical care. While Bacillus Calmette–Guérin (BCG) is the most widely used… read more here.
Keywords: outer membrane; immunity; membrane vesicles; trained immunity ... See more keywords
The Fluidity of the Bacterial Outer Membrane Is Species Specific
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DOI: 10.1002/bies.201900246
Abstract: The outer membrane (OM) is an essential barrier that guards Gram‐negative bacteria from diverse environmental insults. Besides functioning as a chemical gatekeeper, the OM also contributes towards the strength and stiffness of cells and allows… read more here.
Keywords: bacterial outer; outer membrane; membrane species; fluidity bacterial ... See more keywords
Single‐molecule approaches reveal outer membrane protein biogenesis dynamics
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DOI: 10.1002/bies.202200149
Abstract: Outer membrane proteins (OMPs) maintain the viability of Gram‐negative bacteria by functioning as receptors, transporters, ion channels, lipases, and porins. Folding and assembly of OMPs involves synchronized action of chaperones and multi‐protein machineries which escort… read more here.
Keywords: single molecule; outer membrane; molecule approaches; biogenesis ... See more keywords
Outer Membrane Vesicles (OMVs) Enabled Bio-applications: A critical review.
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DOI: 10.1002/bit.27965
Abstract: Outer membrane vesicles (OMVs) are nanoscale spherical vesicles released from Gram-negative bacteria. The lipid bilayer membrane structure of OMVs consists of the similar components as bacterial membrane and thus has attracted more and more attention… read more here.
Keywords: bio applications; membrane vesicles; vesicles omvs; outer membrane ... See more keywords
The Serratia grimesii outer membrane vesicles‐associated grimelysin triggers bacterial invasion of eukaryotic cells
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DOI: 10.1002/cbin.11435
Abstract: Serratia grimesii are facultative pathogenic bacteria that can penetrate a wide range of host cells and cause infection, especially in immunocompromised patients. Previously, we have found that bacterial metalloprotease grimelysin is a potential virulence determinant… read more here.
Keywords: grimesii; serratia grimesii; outer membrane; grimelysin ... See more keywords
Investigation of selected parameters of capillary zone electrophoresis method for analysis of isolates of outer membrane vesicles
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DOI: 10.1002/elps.202000360
Abstract: The capillary zone electrophoresis (CZE) has recently been proposed by our group as a novel technique for outer membrane vesicles (OMVs) characterization (J. Chromatography 1621 (2020) 461047). In present work the impact of selected parameters… read more here.
Keywords: membrane vesicles; outer membrane; capillary zone; electrophoresis ... See more keywords