A pair of residue substitutions at the outer mouth of the channel pore act as inputs for a Boolean logic "OR" gate based on the glycine receptor.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00522
Abstract: The glycine receptor (GlyR) is a ligand-activated chloride channel, whose mutations are the major cause of hereditary hyperekplexia. The hyperekplexia-causing R271Q mutation, which is located at the extracellular outer mouth of the channel pore, dramatically… read more here.
Keywords: mouth channel; gate; glycine receptor; glyr ... See more keywords