Insights into photoreceptor ciliogenesis revealed by animal models
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2018.12.004
Abstract: Photoreceptors are polarized neurons, with very specific subcellular compartmentalization and unique requirements for protein expression and trafficking. Each photoreceptor contains an outer segment, the site of photon capture that initiates vision, an inner segment that… read more here.
Keywords: ciliogenesis; connecting cilium; photoreceptor ciliogenesis; outer segment ... See more keywords
Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02514-5
Abstract: Mutations in the photoreceptor outer segment (OS) specific peripherin-2 lead to autosomal dominant retinitis pigmentosa (adRP). By contrast, mutations in the peripherin-2 homolog Rom-1 cause digenic RP in combination with certain heterozygous mutations in peripherin-2.… read more here.
Keywords: permt; outer segment; retinitis pigmentosa; rom ... See more keywords
PRCD is Concentrated at the Base of Photoreceptor Outer Segments and is Involved in Outer Segment Disc Formation.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz248
Abstract: Mutations of the PRCD gene are associated with rod-cone degeneration in both dogs and humans. Prcd is expressed in the mouse eye as early as embryonic day 14. In the adult mouse retina PRCD is… read more here.
Keywords: photoreceptor outer; segment; outer segment; microscopy ... See more keywords
PHOTORECEPTOR OUTER SEGMENT IS EXPANDED IN THE FELLOW EYE OF PATIENTS WITH UNILATERAL CENTRAL SEROUS CHORIORETINOPATHY.
Sign Up to like & getrecommendations! Published in 2020 at "Retina"
DOI: 10.1097/iae.0000000000002846
Abstract: PURPOSE To quantitatively evaluate the photoreceptor structural changes in the fellow unaffected eyes of patients with unilateral central serous chorioretinopathy (CSC). METHODS This is a retrospective cross-sectional study. We analyzed data from patients with diagnosis… read more here.
Keywords: photoreceptor outer; csc; photoreceptor; outer segment ... See more keywords
Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered X. laevis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.253906
Abstract: Mutations in prominin-1 (prom1) and photoreceptor cadherin (cdhr1) are associated with inherited retinal degenerative disorders but their functions remain unknown. We used CRISPR-Cas9 to generate prom1-, cdhr1-, and prom1+cdhr1-null X. laevis and then documented the… read more here.
Keywords: disc; cdhr1; photoreceptor; outer segment ... See more keywords
Loss of Pde6a Induces Rod Outer Segment Shrinkage and Visual Alterations in pde6aQ70X Mutant Zebrafish, a Relevant Model of Retinal Dystrophy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.675517
Abstract: Retinitis pigmentosa (RP) is one of the most common forms of inherited retinal degeneration with 1/4,000 people being affected. The vision alteration primarily begins with rod photoreceptor degeneration, then the degenerative process continues with cone… read more here.
Keywords: pde6aq70x mutant; rod outer; outer segment; segment shrinkage ... See more keywords
Probing Photoreceptor Outer Segment Phagocytosis by the RPE In Vivo: Models and Methodologies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073661
Abstract: In the vertebrate retina, the light-sensitive photoreceptor rods and cones constantly undergo renewal by generating new portions of the outer segment and shedding their distal, spent tips. The neighboring RPE provides the critical function of… read more here.
Keywords: methodology; rpe; phagocytosis; rpe phagocytosis ... See more keywords
Differences in Diurnal Rhythm of Rod Outer Segment Renewal between 129T2/SvEmsJ and C57BL/6J Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169466
Abstract: In all mammalian species tested to date, rod photoreceptor outer segment renewal is a circadian process synchronized by light with a burst of outer segment fragment (POS) shedding and POS phagocytosis by the adjacent retinal… read more here.
Keywords: segment; segment renewal; outer segment; mice ... See more keywords