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   Articles with "outer segment" as a keyword



Insights into photoreceptor ciliogenesis revealed by animal models

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recommendations! Published in 2019 at "Progress in Retinal and Eye Research"

DOI: 10.1016/j.preteyeres.2018.12.004

Abstract: Photoreceptors are polarized neurons, with very specific subcellular compartmentalization and unique requirements for protein expression and trafficking. Each photoreceptor contains an outer segment, the site of photon capture that initiates vision, an inner segment that… read more here.

Keywords: ciliogenesis; connecting cilium; photoreceptor ciliogenesis; outer segment ... See more keywords

Ciliary tip actin dynamics regulate photoreceptor outer segment integrity

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-48639-w

Abstract: As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (discs) at the tip… read more here.

Keywords: outer segment; actin dynamics; photoreceptor; actin ... See more keywords

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-02514-5

Abstract: Mutations in the photoreceptor outer segment (OS) specific peripherin-2 lead to autosomal dominant retinitis pigmentosa (adRP). By contrast, mutations in the peripherin-2 homolog Rom-1 cause digenic RP in combination with certain heterozygous mutations in peripherin-2.… read more here.

Keywords: permt; outer segment; retinitis pigmentosa; rom ... See more keywords

PRCD is Concentrated at the Base of Photoreceptor Outer Segments and is Involved in Outer Segment Disc Formation.

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recommendations! Published in 2019 at "Human molecular genetics"

DOI: 10.1093/hmg/ddz248

Abstract: Mutations of the PRCD gene are associated with rod-cone degeneration in both dogs and humans. Prcd is expressed in the mouse eye as early as embryonic day 14. In the adult mouse retina PRCD is… read more here.

Keywords: photoreceptor outer; segment; outer segment; microscopy ... See more keywords

PHOTORECEPTOR OUTER SEGMENT IS EXPANDED IN THE FELLOW EYE OF PATIENTS WITH UNILATERAL CENTRAL SEROUS CHORIORETINOPATHY.

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recommendations! Published in 2020 at "Retina"

DOI: 10.1097/iae.0000000000002846

Abstract: PURPOSE To quantitatively evaluate the photoreceptor structural changes in the fellow unaffected eyes of patients with unilateral central serous chorioretinopathy (CSC). METHODS This is a retrospective cross-sectional study. We analyzed data from patients with diagnosis… read more here.

Keywords: photoreceptor outer; csc; photoreceptor; outer segment ... See more keywords

Photoreceptor calyceal processes accompany the developing outer segment, adopting a stable length despite a dynamic core

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recommendations! Published in 2024 at "Journal of Cell Science"

DOI: 10.1101/2023.10.04.560921

Abstract: Vertebrate photoreceptors detect light through a large cilium-based outer segment, which is filled with photopigment-laden membranous discs. Surrounding the base of the outer segment are microvilli-like calyceal processes (CPs). While CP disruption has been associated… read more here.

Keywords: outer segment; segment; calyceal processes; photoreceptor ... See more keywords

Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered X. laevis.

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recommendations! Published in 2020 at "Journal of cell science"

DOI: 10.1242/jcs.253906

Abstract: Mutations in prominin-1 (prom1) and photoreceptor cadherin (cdhr1) are associated with inherited retinal degenerative disorders but their functions remain unknown. We used CRISPR-Cas9 to generate prom1-, cdhr1-, and prom1+cdhr1-null X. laevis and then documented the… read more here.

Keywords: disc; cdhr1; photoreceptor; outer segment ... See more keywords

Loss of Pde6a Induces Rod Outer Segment Shrinkage and Visual Alterations in pde6aQ70X Mutant Zebrafish, a Relevant Model of Retinal Dystrophy

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.675517

Abstract: Retinitis pigmentosa (RP) is one of the most common forms of inherited retinal degeneration with 1/4,000 people being affected. The vision alteration primarily begins with rod photoreceptor degeneration, then the degenerative process continues with cone… read more here.

Keywords: pde6aq70x mutant; rod outer; outer segment; segment shrinkage ... See more keywords

Probing Photoreceptor Outer Segment Phagocytosis by the RPE In Vivo: Models and Methodologies

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23073661

Abstract: In the vertebrate retina, the light-sensitive photoreceptor rods and cones constantly undergo renewal by generating new portions of the outer segment and shedding their distal, spent tips. The neighboring RPE provides the critical function of… read more here.

Keywords: methodology; rpe; phagocytosis; rpe phagocytosis ... See more keywords

Differences in Diurnal Rhythm of Rod Outer Segment Renewal between 129T2/SvEmsJ and C57BL/6J Mice

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23169466

Abstract: In all mammalian species tested to date, rod photoreceptor outer segment renewal is a circadian process synchronized by light with a burst of outer segment fragment (POS) shedding and POS phagocytosis by the adjacent retinal… read more here.

Keywords: segment; segment renewal; outer segment; mice ... See more keywords

Thickened photoreceptor outer segment layer in children with hyperopic anisometropic amblyopia

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recommendations! Published in 2024 at "Indian Journal of Ophthalmology"

DOI: 10.4103/ijo.ijo_3068_23

Abstract: Purpose. To quantitatively investigate the reflectivity and structure of the outer retinal layers in children with hyperopic anisometropic amblyopia by using swept-source optical coherence tomography (SS-OCT). Methods: Seventy-eight patients with amblyopia and 64 age-matched children… read more here.

Keywords: outer segment; photoreceptor outer; layer; amblyopia ... See more keywords