The β8 integrin EGF domains support a constitutive extended conformation, and the cytoplasmic domain impairs outside‐in signaling
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DOI: 10.1002/jcp.30871
Abstract: Integrins are transmembrane proteins that transmit bi‐directional signals across the cell membrane through global structural rearrangement among three different conformational states: bent, extended‐ closed, and extended‐open conformations. However, the β8 integrin is distinctive and may… read more here.
Keywords: conformation; ligand binding; outside signaling; extended conformation ... See more keywords
Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases
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DOI: 10.1161/atvbaha.120.314902
Abstract: Supplemental Digital Content is available in the text. Objective: Reelin, a secreted glycoprotein, was originally identified in the central nervous system, where it plays an important role in brain development and maintenance. In the cardiovascular… read more here.
Keywords: activation; alphaiib beta3; integrin outside; beta3 integrin ... See more keywords
Shear and Integrin Outside-In Signaling Activate NADPH-Oxidase 2 to Promote Platelet Activation
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DOI: 10.1161/atvbaha.120.315773
Abstract: Supplemental Digital Content is available in the text. Objective: Despite the importance of reactive oxygen species (ROS) and NOX (nicotinamide adenine dinucleotide phosphate [NADPH] oxidase) 2 in platelet activation and in vivo thrombosis, it is… read more here.
Keywords: activation; outside signaling; ros generation; platelet ... See more keywords
Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets
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DOI: 10.1371/journal.pone.0176602
Abstract: Background It is believed that activation of c-Src bound to the integrin β3 subunit initiates outside-in signaling. The involvement of αIIb in outside-in signaling is poorly understood. Objectives We have previously shown that CIB1 specifically… read more here.
Keywords: iib required; cib1 iib; outside signaling; activation ... See more keywords
Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signaling
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DOI: 10.1371/journal.pone.0260593
Abstract: Cadherins control intercellular adhesion in most metazoans. In vertebrates, intercellular adhesion differs considerably between cadherins of type-I and type-II, predominantly due to their different extracellular regions. Yet, intercellular adhesion critically depends on actomyosin contractility, in… read more here.
Keywords: outside signaling; cell; cadherin; cell cell ... See more keywords
Characterization of Integrin αIIbβ3-Mediated Outside-in Signaling by Protein Kinase Cδ in Platelets
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DOI: 10.3390/ijms21186563
Abstract: Engagement of integrin αIIbβ3 promotes platelet–platelet interaction and stimulates outside-in signaling that amplifies activation. Protein kinase Cδ (PKCδ) is known to play an important role in platelet activation, but its role in outside-in signaling has… read more here.
Keywords: iib mediated; integrin iib; outside signaling; role ... See more keywords