Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism
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DOI: 10.1038/s41467-018-06306-x
Abstract: Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major… read more here.
Keywords: medicine; facilitator superfamily; antiporter; conformation ... See more keywords