A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104484
Abstract: The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may… read more here.
Keywords: shp2; ajuga ovalifolia; abietane diterpenoid; var calantha ... See more keywords
Hebecarposides A-K, antiproliferative lanostane-type triterpene glycosides from the leaves of Lyonia ovalifolia var. hebecarpa.
Sign Up to like & getrecommendations! Published in 2018 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2018.03.012
Abstract: Eleven previously undescribed lanostane-type triterpene glycosides, hebecarposides A-K, were isolated from the leaves of Lyonia ovalifolia var. hebecarpa (Ericaceae), along with two known analogues, lyonifolosides L and O. The structures of hebecarposides A-K were established… read more here.
Keywords: var hebecarpa; type triterpene; lanostane type; triterpene glycosides ... See more keywords
A new abietane diterpenoid glycoside from ajuga ovalifolia var. calantha
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1500574
Abstract: Abstract A new abietane diterpenoid glycoside, ajugaside B (1), along with three known compounds (2–4), were isolated from the whole plants of Ajuga ovalifolia var. calantha. The structure of the new compound (1) was elucidated… read more here.
Keywords: ajuga ovalifolia; abietane diterpenoid; var calantha; diterpenoid glycoside ... See more keywords