Ovarian Aging and Osteoporosis.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-1117-8_13
Abstract: Osteoporosis is the most common bone metabolic disease with a very high morbidity, and women usually got a higher risk of osteoporosis than men. The high incidence rate of osteoporosis in women was mainly caused… read more here.
Keywords: estrogen; osteoporosis; aging osteoporosis; biology ... See more keywords
Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway
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DOI: 10.1016/j.gendis.2020.08.005
Abstract: Abstract Cellular senescence is closely associated with age-related diseases. Ovarian aging, a special type of organ senescence, is the pathophysiological foundation of the diseases of the reproductive system. It is characterized by the loss of… read more here.
Keywords: ythdf2 mapk; ythdf2; senescence; mapk pathway ... See more keywords
A roadmap for NHP ovarian aging
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DOI: 10.1038/s41684-020-0515-3
Abstract: Ovarian aging is associated with a decrease in follicle number and oocyte quality, resulting in a gradual decline in female fertility. The molecular mechanisms driving ovarian aging remain unclear, hampering the development of interventions to… read more here.
Keywords: roadmap nhp; nhp ovarian; cell; ovarian aging ... See more keywords
Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02042-z
Abstract: Studies have shown that melatonin (MLT) can delay ovarian aging, but the mechanism has not been fully elucidated. Here we show that granulosa cells isolated from mice follicles can synthesize MLT; the addition of MLT… read more here.
Keywords: follicle activation; delays ovarian; mice; growth ... See more keywords
An Oxidative Stress-Related Gene Signature in Granulosa Cells Is Associated with Ovarian Aging
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1070968
Abstract: Ovarian aging is associated with a decrease in fecundity. Increased oxidative stress of granulosa cells (GCs) is an important contributor. We thus asked whether there is an oxidative stress-related gene signature in GCs associated with… read more here.
Keywords: stress; stress related; signature; oxidative stress ... See more keywords
The Molecular Regulation in the Pathophysiology in Ovarian Aging
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DOI: 10.14336/ad.2020.1113
Abstract: The female reproductive system is of great significance to women’s health. Aging of the female reproductive system occurs approximately 10 years prior to the natural age-associated functional decline of other organ systems. With an increase… read more here.
Keywords: pathophysiology ovarian; health; ovarian aging; molecular regulation ... See more keywords
Premature ovarian aging in BRCA carriers: a prototype of systemic precocious aging?
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24638
Abstract: Purpose Though former evidence implies a correlation of breast cancer susceptibility gene (BRCA) mutation with reduced ovarian reserve, the data is yet inconsistent. Our aim was to investigate biomarkers of ovarian aging in a cohort… read more here.
Keywords: aging brca; brca mutation; brca; premature ovarian ... See more keywords
Regulation of ovarian function by growth hormone: Potential intervention of ovarian aging
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1072313
Abstract: Growth hormone (GH) is mainly secreted by eosinophils of anterior pituitary gland. GH plays an important role in regulating the growth and development of many tissues and cells, so it is used in the treatment… read more here.
Keywords: growth; growth hormone; ovarian aging; ovarian function ... See more keywords
Editorial: Ovarian aging and reproduction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1081348
Abstract: COPYRIGHT © 2022 Liu, Zhang, Li, Xu and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is… read more here.
Keywords: ovarian aging; editorial ovarian; aging reproduction; reproduction ... See more keywords
Accelerated Ovarian Aging Among Type 2 Diabetes Patients and Its Association With Adverse Lipid Profile
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DOI: 10.3389/fendo.2022.780979
Abstract: Background The impact of diabetes on reproductive function is still not clearly defined. This study aimed to evaluate accelerated ovarian aging in women with type 2 diabetes mellitus (T2DM) and its association with adverse lipid… read more here.
Keywords: ovarian aging; accelerated ovarian; patients t2dm; t2dm controls ... See more keywords
The prognostic significance of human ovarian aging-related signature in breast cancer after surgery: A multicohort study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1139797
Abstract: Background Recent studies have shown that ovarian aging is strongly associated with the risk of breast cancer, however, its prognostic impact on breast cancer is not yet fully understood. In this study, we performed a… read more here.
Keywords: signature; breast cancer; risk; ovarian aging ... See more keywords