Outcomes From Opportunistic Salpingectomy for Ovarian Cancer Prevention
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.47343
Abstract: Key Points Question Is opportunistic salpingectomy associated with fewer than expected ovarian cancers? Findings This population-based cohort study included 25 889 individuals who underwent opportunistic salpingectomy and 32 080 individuals who underwent hysterectomy alone or tubal ligation.… read more here.
Keywords: salpingectomy; opportunistic salpingectomy; ovarian cancers; ovarian cancer ... See more keywords
Mithplatins: Mithramycin SA‐Pt(II) Complex Conjugates for the Treatment of Platinum‐Resistant Ovarian Cancers
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200368
Abstract: DNA coordinating platinum (Pt) containing compounds cisplatin and carboplatin have been used for the treatment of ovarian cancer therapy for four decades. However, recurrent Pt‐resistant cancers are a major cause of mortality. To combat Pt‐resistant… read more here.
Keywords: dna; ovarian cancers; ovarian cancer; resistant ovarian ... See more keywords
Survival of patients with advanced and recurrent ovarian cancer treated using integrative medicine in Malaysia: A case series.
Sign Up to like & getrecommendations! Published in 2019 at "Complementary therapies in clinical practice"
DOI: 10.1016/j.ctcp.2019.09.001
Abstract: BACKGROUND This case series describes the survival outcomes of patients who underwent integrative medicine (IM) protocol for ovarian cancer, a treatment protocol, that integrated a carefully selected set of complementary and alternative medicine (CAM) into… read more here.
Keywords: medicine; case series; ovarian cancers; ovarian cancer ... See more keywords
Does the primary site really matter? Profiling mucinous ovarian cancers of uncertain primary origin (MO-CUP) to personalise treatment and inform the design of clinical trials.
Sign Up to like & getrecommendations! Published in 2018 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2018.07.013
Abstract: OBJECTIVE Advanced stage mucinous ovarian cancers are diagnostically and therapeutically challenging. Histotype specific trials have failed due to low recruitment after excluding non-ovarian primaries. Mucinous ovarian cancers are commonly metastatic from other sites however lack… read more here.
Keywords: cancers uncertain; treatment; ovarian cancers; clinical trials ... See more keywords
ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.02.014
Abstract: PURPOSE PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic lethality in platinum sensitive sporadic disease is yet to be defined. ERCC1-XPF heterodimer is a key… read more here.
Keywords: platinum sensitivity; platinum; ercc1 xpf; ovarian cancers ... See more keywords
The disparate origins of ovarian cancers: pathogenesis and prevention strategies
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cancer"
DOI: 10.1038/nrc.2016.113
Abstract: Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that… read more here.
Keywords: origins ovarian; ovarian cancers; cancers pathogenesis; disparate origins ... See more keywords
Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01710-y
Abstract: Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers. However, not all patients respond due to intrinsic or acquired resistance to PARP1 inhibitor.… read more here.
Keywords: synthetic lethality; ovarian cancers; platinum; dna polymerase ... See more keywords
Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00263-7
Abstract: The lack of effective chemotherapies for high-grade serous ovarian cancers (HGS-OvCa) has motivated a search for alternative treatment strategies. Here, we present an unbiased systems-approach to interrogate a panel of 14 well-annotated HGS-OvCa patient-derived xenografts… read more here.
Keywords: hgs ovca; analysis; drug response; drug ... See more keywords
Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88382-6
Abstract: Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with context-dependent implications to both tumor-promoting and -suppressive processes in ways that remain incompletely understood. Using ovarian cancer tissue… read more here.
Keywords: epha2; aggressive recurrent; ovarian cancers; recurrent ovarian ... See more keywords
Short divalent ethacrynic amides as pro-inhibitors of glutathione S-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2038591
Abstract: Abstract The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine gave EDEA and BDEA, respectively, as membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST). Their divalent glutathione conjugates showed subnanomolar inhibition and divalence-binding to GSTmu (GSTM)… read more here.
Keywords: inhibitors glutathione; glutathione transferase; pro inhibitors; ovarian cancers ... See more keywords
Immunology and ovarian cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000283
Abstract: The current standard therapy of epithelial ovarian cancer (EOC) is the combination of surgery and multi-agent chemotherapy with/without adding targeted therapy. After treatment, response rate is high and nearly all patients can achieve complete remission,… read more here.
Keywords: therapy; ovarian cancers; treatment; immunology ... See more keywords