Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low‐grade ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34661
Abstract: Advanced low‐grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed in patients with LGOC, which suggests that antihormonal therapy (AHT) is a treatment option. However,… read more here.
Keywords: estrogen receptor; activity; low grade; grade ovarian ... See more keywords
The activation of M2 muscarinic receptor inhibits cell growth and survival in human epithelial ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30303
Abstract: Ovarian cancer is the fifth leading cause of cancer‐related deaths in females. Many ovarian tumor cell lines express muscarinic receptors (mAChRs), and their expression is correlated with reduced survival of patients. We have characterized the… read more here.
Keywords: cell; cell growth; cell lines; ovarian carcinoma ... See more keywords
LncRNA LIFR‐AS1 overexpression suppressed the progression of serous ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24570
Abstract: Serous ovarian carcinoma (SOC) is a common malignant tumor in female reproductive system. Long noncoding RNA (lncRNA) LIFR‐AS1 is a tumor suppressor gene in colorectal cancer, but its effect and underlying mechanism in SOC are… read more here.
Keywords: lifr as1; serous ovarian; lncrna lifr; ovarian carcinoma ... See more keywords
Functional tumour burden of peritoneal carcinomatosis derived from DWI could predict incomplete tumour debulking in advanced ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "European Radiology"
DOI: 10.1007/s00330-020-06887-6
Abstract: To investigate the predictive value of peritoneal carcinomatosis (PC) quantification by DWI in determining incomplete tumour debulking in ovarian carcinoma (OC). Prospective patients with suspected stage III–IV or recurrent OC were recruited for DWI before… read more here.
Keywords: tumour debulking; dwi; burden; ovarian carcinoma ... See more keywords
Advanced stage primary mucinous ovarian carcinoma. Where do we stand ?
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05489-3
Abstract: Objective To evaluate factors associated with survival of patients with advanced stage mucinous ovarian carcinoma (MOC) using a large multi-institutional database. Methods Patients diagnosed between 2004 and 2014 with advanced stage (III–IV) MOC were identified… read more here.
Keywords: mucinous ovarian; advanced stage; stage primary; stage ... See more keywords
Proteomic investigating the cooperative lethal effect of EGFR and MDM2 inhibitors on ovarian carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.04.004
Abstract: With the concept of precision medicine, combining multiple molecular-targeting therapies has brought new approaches to current cancer treatments. Malfunction of the tumor suppressor protein, p53 is a universal hallmark in human cancers. Under normal conditions,… read more here.
Keywords: egfr; mdm2 inhibitors; mdm2; inhibition ... See more keywords
Axl molecular targeting counteracts aggressiveness but not platinum‐resistance of ovarian carcinoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.04.002
Abstract: Graphical abstract Figure. No Caption available. Abstract Ovarian carcinoma, the most common gynaecological cancer, is characterized by high lethality mainly due to late diagnosis and treatment failure. The efficacy of platinum drug‐based therapy in the… read more here.
Keywords: igrov pt1; resistance; carcinoma; ovarian carcinoma ... See more keywords
Si113-prodrugs selectively activated by plasmin against hepatocellular and ovarian carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113653
Abstract: Si113, a pyrazolo[3,4-d]pyrimidine derivative, gained more attention as an anticancer agent due to its potent anticancer activity on both in vitro and in vivo hepatocellular carcinomas (HCC) and ovarian carcinoma models. But the drawback is the low… read more here.
Keywords: hcc; carcinoma; si113 prodrugs; prodrugs selectively ... See more keywords
Synchronous carcinomas of endometrium and ovary: A pragmatic approach
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2018.12.009
Abstract: In a recent issue of Gynecologic Oncology Turashvili and colleagues from Memorial Sloan Kettering Cancer Center reported on a series of 74 women with concurrent carcinoma involving endometrium and ovary, 19 of which were considered… read more here.
Keywords: independent primary; endometrium; endometrium ovary; carcinomas ... See more keywords
HDAC10 as a potential therapeutic target in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.01.009
Abstract: OBJECTIVE We analyzed histone deacetylase 10 (HDAC10) for function in the context of the DNA damage response in BRCA1-null ovarian cancer cells as well as evaluated the potential of general HDAC inhibitors in primary ovarian… read more here.
Keywords: platinum; dna; hdac10; ovarian cancer ... See more keywords
Probability of detecting germline BRCA1/2 pathogenic variants in histological subtypes of ovarian carcinoma. A meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2021.10.072
Abstract: BACKGROUND Histology restricted genetic predisposition testing of ovarian carcinoma patients is a topic of debate as the prevalence of BRCA1/2 pathogenic variants (PVs) in various histological subtypes is ambiguous. Our primary aim was to investigate… read more here.
Keywords: histological subtypes; brca1; ovarian carcinoma; germline brca1 ... See more keywords