Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-021-02081-9
Abstract: Is it possible to eliminate metastasised chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells from ovarian cortex fragments by inhibition of Aurora B/C kinases (AURKB/C) without compromising ovarian tissue or follicles? Human ovarian… read more here.
Keywords: ovarian cortex; cortex; treatment; tissue ... See more keywords
Laparoscopic ovarian tissue harvesting and orthotopic ovarian cortex grafting for fertility preservation: less is more.
Sign Up to like & getrecommendations! Published in 2019 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2018.11.022
Abstract: OBJECTIVE To describe our surgical techniques for laparoscopic ovarian tissue harvesting and orthotopic ovarian cortex grafting (LOOCG). DESIGN This video article uses surgical cases to demonstrate the detailed surgical techniques. Institutional Review Board approval was… read more here.
Keywords: ovarian cortex; cortex grafting; tissue harvesting; cortex ... See more keywords
VEGFA165 can rescue excess steroid secretion, inflammatory markers and follicle arrest in the ovarian cortex of high A4 cows.
Sign Up to like & getrecommendations! Published in 2021 at "Biology of reproduction"
DOI: 10.1093/biolre/ioab201
Abstract: A population of cows with excess androstenedione (A4; High A4) in follicular fluid, with follicular arrest, granulosa cell dysfunction, and a 17% reduction in calving rate was previously identified. We hypothesized that excess A4 in… read more here.
Keywords: ovarian cortex; secretion; cortex; high cows ... See more keywords
O-191 Assessing the use of tumour-specific DARPin-toxin fusion proteins for ex vivo purging of cancer metastases from human ovarian cortex tissue fragments before autotransplantation
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction"
DOI: 10.1093/humrep/deab127.092
Abstract: Is it possible to eradicate cancer cells from ovarian cortex by using tumour-specific designed ankyrin repeat protein (DARPin)-toxin fusion proteins, without compromising the ovarian tissue? Purging ovarian cortex ex vivo from experimentally induced breast cancer… read more here.
Keywords: darpin; ovarian cortex; darpin toxin; tissue ... See more keywords
Naturally occurring androgen excess cows are present in dairy and beef herds and have similar characteristics to women with PCOS.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac151
Abstract: Beef cows with excess androstenedione (A4; High A4) in follicular fluid (FF) and secreted by the ovarian cortex have been reported from the University of Nebraska-Lincoln physiology herd displaying characteristics reminiscent of polycystic ovary syndrome… read more here.
Keywords: ovarian cortex; dairy; present dairy; beef ... See more keywords
165 Randel Lecture: Androgen Excess Domestic Livestock Models—What can they Tell us About the Mechanisms Underlying Anovulation?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Animal Science"
DOI: 10.1093/jas/skad068.080
Abstract: Ovulatory disorders are a major factor in female infertility. Our laboratory has identified several populations of cows and a population of sheep that have excess androgen (High A4) in dominant follicles and ovarian cortex cultures… read more here.
Keywords: follicular arrest; androgen excess; ovarian cortex; cortex ... See more keywords
Ovarian Stem Cells (OSCs) from the Cryopreserved Ovarian Cortex: A Potential for Neo-Oogenesis in Women with Cancer-Treatment Related Infertility: A Case Report and a Review of Literature
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44050157
Abstract: Cancer treatment related infertility (CTRI) affects more than one third of young women undergoing anti-cancer protocols, inducing a premature exhaustion of the ovarian reserve. In addition to ovarian suppression by GnRHa, oocyte and cortex cryopreservation… read more here.
Keywords: treatment related; ovarian cortex; cancer treatment; cortex ... See more keywords
Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21093245
Abstract: Novel anti-cancer treatments have improved the survival rates of female young patients, reopening pregnancy issues for female cancer survivors affected by the tumor treatment-related infertility. This condition occurs in approximately one third of women of… read more here.
Keywords: ovarian cortex; cortex; cortex biobanking; human ovarian ... See more keywords