Trends in actionable mutations for recurrent ovarian and endometrial cancer at a single institution
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)01249-x
Abstract: Objectives: To identify actionable gene mutations in recurrent ovarian and endometrial cancer and to evaluate the effect of these cancer specific mutations on survival outcomes at a single institution. Methods: This was an institutional review… read more here.
Keywords: mutations recurrent; endometrial cancer; recurrent ovarian; cancer ... See more keywords
Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58183-w
Abstract: Ovarian cancers (OVCAs) and endometrial cancers (EMCAs) with CCNE1-amplification are often resistant to standard treatment and represent an unmet clinical need. Synthetic-lethal screening identified loss of the CDK1 regulator, PKMYT1, as synthetically lethal with CCNE1-amplification.… read more here.
Keywords: ccne1; ovarian endometrial; pkmyt1; endometrial cancers ... See more keywords
Current management of hereditary cancer syndromes in ovarian and endometrial cancer: a Japanese study.
Sign Up to like & getrecommendations! Published in 2025 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyaf176
Abstract: BACKGROUND To evaluate the current state of hereditary cancer syndrome management in patients with ovarian and endometrial cancer and to identify the barriers to uptake of genetic testing. METHODS We conducted a cross-sectional multicenter study… read more here.
Keywords: cancer; ovarian endometrial; hereditary cancer; endometrial cancer ... See more keywords
Low-dose lenvatinib and anti-programmed cell death protein-1 combination therapy in patients with heavily pre-treated recurrent ovarian and endometrial cancer: a pilot study
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2024-005331
Abstract: Objective Treatment options for heavily pre-treated recurrent ovarian and endometrial cancer are limited. Lenvatinib plus anti-programmed cell death protein-1 (PD-1) combination therapy has been efficacious in advanced endometrial cancer, but at the recommended dose level,… read more here.
Keywords: cancer; ovarian endometrial; pre treated; therapy ... See more keywords
Abstract 6522: Improved detection of low frequency mutations in ovarian and endometrial cancers by utilizing a highly accurate sequencing platform
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6522
Abstract: Ovarian and endometrial cancers come within the top-4 for incident cancers as well as deaths in North American women. Cure rates have not improved in 30 years as high-grade subtypes continue to be diagnosed in… read more here.
Keywords: ovarian endometrial; endometrial cancers; accurate sequencing; highly accurate ... See more keywords
The Role of Statins in the Prevention of Ovarian and Endometrial Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer prevention research"
DOI: 10.1158/1940-6207.capr-22-0374
Abstract: Ovarian and endometrial cancers are the most common gynecologic malignancies and emerging evidence suggests that lipid metabolism and subsequent inflammation are important etiologic factors for both tumors. Statins (HMG-CoA reductase inhibitors) are the most widely… read more here.
Keywords: ovarian endometrial; endometrial cancers; role; prevention ... See more keywords
The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
Sign Up to like & getrecommendations! Published in 2020 at "Women's Health"
DOI: 10.1177/1745506520961710
Abstract: Drug repurposing is the application of an existing licenced drug for a new indication and potentially provides a faster and cheaper approach to developing new anti-cancer agents. Gynaecological cancers contribute significantly to the global cancer… read more here.
Keywords: endometrial cervical; role aspirin; cancer; prevention ... See more keywords
Targeting synthetic lethality: an effective therapeutic approach in ovarian and endometrial cancers
Sign Up to like & getrecommendations! Published in 2025 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/17588359251392106
Abstract: Synthetic lethality (SL) is a promising therapeutic concept that relies on the indirect targeting of vulnerabilities acquired through genetic mutations. Ovarian and endometrial cancers frequently exhibit mutations in the breast cancer (BRCA), phosphatase and tensin… read more here.
Keywords: lethality; ovarian endometrial; synthetic lethality; endometrial cancers ... See more keywords
Understanding How Pregnancy Protects Against Ovarian and Endometrial Cancer Development: Fetal Antigens May Be Involved
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac141
Abstract: Abstract It is well known that many factors, including infertility, obesity, type 2 diabetes, and family history of cancer, increase the risk of developing endometrial and ovarian cancer. However, multiparous women are known to have… read more here.
Keywords: endometrial cancer; fetal antigens; pregnancy protects; ovarian endometrial ... See more keywords
Chemoresistance and targeted therapies in ovarian and endometrial cancers
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14021
Abstract: Gynecological cancers are known for being very aggressive at their advanced stages. Indeed, the survival rate of both ovarian and endometrial cancers is very low when diagnosed lately and the success rate of current chemotherapy… read more here.
Keywords: chemoresistance; chemoresistance targeted; ovarian endometrial; therapies ovarian ... See more keywords
Contrast-enhanced ultrasound evaluation of a refractory ovarian endometrial cyst and ultrasound-guided aspiration sclerotherapy using urokinase and lauromacrogol.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical hemorheology and microcirculation"
DOI: 10.3233/ch-211134
Abstract: Endometriosis is one of the most common diseases that happen in reproductive women. The main symptoms include ovarian endometrial cyst, pelvic pain, and so on. We report a case of a 23-year-old woman with a… read more here.
Keywords: sclerotherapy; endometrial cyst; ovarian endometrial; cyst ... See more keywords