Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9144644
Abstract: Ovarian damage induced by platinum-based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency. However, effective prevention strategies for such damage are lacking. Senescent cells may be induced… read more here.
Keywords: damage; dna damage; senescent cells; cisplatin induced ... See more keywords
The effects of metyrosine on ischemia-reperfusion-induced oxidative ovarian injury in rats: Biochemical and histopathological assessment.
Sign Up to like & getrecommendations! Published in 2023 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202320201586
Abstract: The aim of this study is to investigate the effect of metyrosine on ischemia-reperfusion (I/R) induced ovarian injury in rats in terms of biochemistry and histopathology. Rats were divided into: ovarian I/R (OIR), ovarian I/R+50… read more here.
Keywords: metyrosine ischemia; group; injury; ischemia reperfusion ... See more keywords
VX-765 has a Protective Effect on Mice with Ovarian Injury Caused by Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Current Cancer Drug Targets"
DOI: 10.2174/1568009622666220930110024
Abstract: Background Malignant tumors continue to remain a main global public health issue. In the past 40 years, due to strides made in multi-disciplinary comprehensive treatment schemes for patients suffering from malignant tumors, especially chemotherapy schemes,… read more here.
Keywords: treated mice; caused chemotherapy; group; mice ... See more keywords
Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study
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DOI: 10.3389/fmed.2021.635255
Abstract: Objective: This study was intended to investigate the relationship between COVID-19 disease and ovarian function in reproductive-aged women. Methods: Female COVID-19 patients of reproductive age were recruited between January 28 and March 8, 2020 from… read more here.
Keywords: ovarian function; reproductive aged; ovarian injury; aged women ... See more keywords
A Docosahexaenoic Acid Derivative (N-Benzyl Docosahexaenamide) as a Potential Therapeutic Candidate for Treatment of Ovarian Injury in the Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092754
Abstract: Commonly used clinical chemotherapy drugs, such as cyclophosphamide (CTX), may cause injury to the ovaries. Hormone therapies can reduce the ovarian injury risk; however, they do not achieve the desired effect and have obvious side… read more here.
Keywords: therapeutic candidate; dha; treatment; injury ... See more keywords