Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
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DOI: 10.1038/s41467-019-13116-2
Abstract: The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial, with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered candidates. Here, by using genetically engineered mouse models and organoids, we assessed… read more here.
Keywords: hgsoc; carcinoma; origin high; epithelium ... See more keywords
Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium
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DOI: 10.1371/journal.pgen.1007788
Abstract: Estrogen therapy increases the risk of ovarian cancer and exogenous estradiol accelerates the onset of ovarian cancer in mouse models. Both in vivo and in vitro, ovarian surface epithelial (OSE) cells exposed to estradiol develop… read more here.
Keywords: single cell; transcriptional dynamics; cell rna; rna sequencing ... See more keywords
IVM Advances for Early Antral Follicle-Enclosed Oocytes Coupling Reproductive Tissue Engineering to Inductive Influences of Human Chorionic Gonadotropin and Ovarian Surface Epithelium Coculture
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DOI: 10.3390/ijms24076626
Abstract: In vitro maturation (IVM) is not a routine assisted reproductive technology (ART) for oocytes collected from early antral (EA) follicles, a large source of potentially available gametes. Despite substantial improvements in IVM in the past… read more here.
Keywords: surface epithelium; maturation; enclosed oocytes; ovarian surface ... See more keywords