Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23164
Abstract: As an environmental contaminant, Benzo[a]pyrene (B[a]P; BaP) disrupts the antioxidant signaling and thus leads to the induction of oxidative stress and the damage of DNA in the ovary. low‐dose atorvastatin (ATV) has antioxidant and anti‐apoptotic… read more here.
Keywords: effect; benzo pyrene; ovarian toxicity; prenatal exposure ... See more keywords
Febuxostat attenuates cyclophosphamide-induced ovarian toxicity; role of TLR4/NFκB/NLRP3 signaling pathway in female wistar albino rats
Sign Up to like & getrecommendations! Published in 2025 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2025.2583496
Abstract: Abstract Background Our goal was to assess if febuxostat (FEB) could prevent ovarian damage caused by cyclophosphamide (CP). Material and methods Four sets were created: control group, FEB group: received FEB 10 mg/kg orally for 14 days,… read more here.
Keywords: induced ovarian; ovarian toxicity; expression; signaling pathway ... See more keywords
Protective effects of Azilsartan against cyclophosphamide-induced ovarian toxicity in rats model.
Sign Up to like & getrecommendations! Published in 2024 at "Toxicology research"
DOI: 10.1093/toxres/tfae027
Abstract: Background Cyclophosphamide (CP) is an effective alkylating anticancer agent that is widely used in cancer chemotherapy, and it can cause ototoxicity and infertility in women. Objectives So, this study aimed to evaluate the protective effects… read more here.
Keywords: protective effects; induced ovarian; compared control; ovarian toxicity ... See more keywords
Abstract 5629: Modeling cyclophosphamide induced ovarian toxicity in a novel translational canine model
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5629
Abstract: Reproductive failure following chemotherapy and/or ionizing radiation is a major adverse event, for which there are no established preventive measures. In previous studies, our laboratory has documented that the selective estrogen receptor modulator, tamoxifen (TAM)… read more here.
Keywords: system; tissue; model; ovarian toxicity ... See more keywords
Ovarian Toxicity Assessment in Histopathological Images Using Deep Learning
Sign Up to like & getrecommendations! Published in 2019 at "Toxicologic Pathology"
DOI: 10.1177/0192623319877871
Abstract: As ovarian toxicity is often a safety concern for cancer therapeutics, identification of ovarian pathology is important in early stages of preclinical drug development, particularly when the intended patient population include women of child-bearing potential.… read more here.
Keywords: deep learning; pathology; toxicity; ovarian toxicity ... See more keywords
Protective effect of alpha-lipoic acid and omega-3 fatty acids against cyclophosphamide-induced ovarian toxicity in rats
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary World"
DOI: 10.14202/vetworld.2020.188-196
Abstract: Background and Aim: Cyclophosphamide therapy is known to be associated with the risk of female infertility as a result of ovarian toxicity. Alpha-lipoic acid (LA) and omega-3 fatty acids are known for their antioxidant and… read more here.
Keywords: cyclophosphamide induced; fatty acids; omega fatty; ovarian toxicity ... See more keywords
Empagliflozin Protects against Haloperidol Experimentally-Induced Ovarian Toxicity
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020168
Abstract: The present experiment aimed to identify the potential protective role of empagliflozin (EMPA) on haloperidol (HAL)-induced ovarian damage in female rats because of its anti-inflammatory, antioxidant, and antiapoptotic effects. EMPA was administered in the presence… read more here.
Keywords: inflammatory apoptotic; oxidative stress; ovarian toxicity; group ... See more keywords