Transcriptomic Profiling Reveals 17β‐Estradiol Treatment Represses Ubiquitin‐Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13698
Abstract: With a decline of 17β‐estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female… read more here.
Keywords: skeletal muscle; treatment; ovariectomized mice; muscle ... See more keywords
Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-024-01555-x
Abstract: Disulfiram (DSF), known as an anti-alcoholism drug, has been reported to suppress osteoclast differentiation in vitro; however, it remains uncertain whether DSF is effective in preventing osteoclastogenesis in vivo. This study aimed to investigate the… read more here.
Keywords: ovariectomized mice; dsf; analysis; osteoclastogenesis ... See more keywords
The combined effects of Teriparatide and Anti-RANKL Monoclonal Antibody on Bone Defect Regeneration in Ovariectomized Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115077
Abstract: OBJECTIVE The purpose of this study was to investigate the combined effects of teriparatide (TPTD) and anti-murine receptor activator of nuclear factor-κB ligand monoclonal antibody (anti-RANKL Ab) on both cancellous and cortical bone healing in… read more here.
Keywords: cortical bone; group; regeneration; bone ... See more keywords
Kamishoyosan potentiates pentobarbital-induced sleep in socially isolated, ovariectomized mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114585
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Sleep disorders are among the most common symptoms in both peri- and post-menopausal women. Kamishoyosan (KSS) is a Kampo medicine prescribed for the treatment of sleep disorders in menopausal women in Japan. However,… read more here.
Keywords: pentobarbital induced; socially isolated; ovariectomized mice; sleeping time ... See more keywords
Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice
Sign Up to like & getrecommendations! Published in 2021 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2021.104948
Abstract: Development of estrogen therapies targeting the β (ERβ) but not α (ERα) estrogen receptor is critically needed for the treatment of negative menopausal symptoms, as ERα activation increases health risks like cancer. Here, we determined… read more here.
Keywords: agonist; estrogen; vasodilation; ovariectomized mice ... See more keywords
Encapsulation of ovarian allograft precludes immune rejection and promotes restoration of endocrine function in immune-competent ovariectomized mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53075-8
Abstract: Premature ovarian insufficiency (POI) is a significant complication of cytotoxic treatments due to extreme ovarian sensitivity to chemotherapy and radiation. POI is particularly devastating for young girls reaching puberty, because it irreversibly affects their physical… read more here.
Keywords: endocrine function; immune competent; ovariectomized mice; competent ... See more keywords
UPLC/Q-TOF-MS-based Metabolomics Study of the Antiosteoporosis Effects of Vaccarin in Ovariectomized Mice
Sign Up to like & getrecommendations! Published in 2022 at "Planta Medica"
DOI: 10.1055/a-1942-5428
Abstract: Abstract Osteoporosis is a systemic and metabolic bone disease that usually occurs in postmenopausal women, which mainly manifests as bone loss and increased bone fragility that both facilitate fracture. However, few drugs for osteoporosis have… read more here.
Keywords: uplc tof; antiosteoporosis; effects vaccarin; tof based ... See more keywords
Urethral proteomic analysis in ovariectomized mice administered 17β-oestradiol replacement therapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2017.1292225
Abstract: Abstract The molecular mechanism by which 17β-oestradiol (E2) increases urethral tone is unclear. As human tissue is limited in availability, we explored changes in the urethras of ovariectomized (OVX) mice. Twenty-four virgin female mice were… read more here.
Keywords: replacement; ovx mice; tone; ovariectomized mice ... See more keywords
0226 A Novel GABAergic Dietary Supplement Enhances Sleep Quality in Ovariectomized Mice
Sign Up to like & getrecommendations! Published in 2024 at "SLEEP"
DOI: 10.1093/sleep/zsae067.0226
Abstract: Sleep disruptions affect 56% of the population. Sleep disorders are common symptoms facing peri- and post-menopausal women. Ovariectomized rodents are a common study model for research on menopausal symptoms. The primary objective of this investigation… read more here.
Keywords: quality; menopausal; brain; ovariectomized mice ... See more keywords
Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Orthopaedic Surgery"
DOI: 10.1111/os.13252
Abstract: To investigate the changes in proinflammatory cytokines and chemokines, namely, C‐C motif ligand (CCL) 2 and CCL7, in postmenopausal osteoporosis (PMOP) and to develop a new drug, bindarit (Bnd), for PMOP in an ovariectomized (OVX)… read more here.
Keywords: loss ovariectomized; bone loss; ccl7; ovariectomized mice ... See more keywords
Crosstalk Between Obesogenic Diet and Estrogen Drives Distinct Microbiota Profiles in Ovariectomized Mice.
Sign Up to like & getrecommendations! Published in 2025 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00184.2025
Abstract: The menopausal transition is associated with an increased obesity risk, which can be ameliorated by hormone replacement therapy. However, the independent and interactive effects of obesity and menopause on the gut microbiota, along with the… read more here.
Keywords: obesity; gut microbiota; estrogen; ovariectomized mice ... See more keywords