MicroRNA-150-5p promotes cell motility by inhibiting c-Myb-mediated Slug suppression and is a prognostic biomarker for recurrent ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1025-x
Abstract: Treatment of ovarian cancer (OvCa) remains challenging owing to its high recurrence rates. Detachment of cancer cells into the peritoneal fluid plays a key role in OvCa relapse, but how this occurs remains incompletely understood.… read more here.
Keywords: ovca; mir 150; ovarian cancer; myb ... See more keywords
Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38766-6
Abstract: Ovarian cancer (OvCa) is the leading cause of death from gynecological malignancies. Five-year survival rate of OvCa ranges from 30–92%, depending on the spread of disease at diagnosis. Role of chemokines is well appreciated in… read more here.
Keywords: ovca; cxcr6; higher cxcl16; cxcl16 ... See more keywords
MiR-588 acts as an oncogene in ovarian cancer and increases the radioresistance of ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrad033
Abstract: Abstract The therapeutic outcomes of ovarian cancer (OVCA) patients are majorly limited by the development of acquired chemo/radioresistance and the lack of targeted therapies. Accumulating studies demonstrate that microRNAs are involved in tumorigenesis and radioresistance.… read more here.
Keywords: mir 588; ovarian cancer; ovca cells; ovca ... See more keywords
Ovarian cancers with low CIP2A tumor expression constitute an APR-246 sensitive disease subtype.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0622
Abstract: Identification of ovarian cancer (OvCa) patient subpopulations with increased sensitivity to targeted therapies could offer significant clinical benefit. We report that 22 % of the high grade OvCa tumors at diagnosis express CIP2A oncoprotein at… read more here.
Keywords: disease; apr 246; cip2a deficient; tumor ... See more keywords
Abstract NTOC-100: OVARIAN TUMOR-ASSOCIATED GRP78 INDUCES IMMUNOSUPPRESSION AND WITHAFERIN A (ASHWAGANDHA) ENHANCES ANTI-TUMOR IMMUNITY
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.ovcasymp16-ntoc-100
Abstract: BACKGROUND: Tumor-induced immunosuppression is a hallmark of tumor progression. Local immune function in the tumor vicinity plays a pivotal role in prevention of OVCA progression. Natural killer (NK) cells and cytotoxic T cells are important… read more here.
Keywords: ovca; tumor associated; anti tumor; immunosuppression ... See more keywords
Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-019-0517-1
Abstract: BackgroundChemokines are involved in the homing of various cancer cells, including those of ovarian cancer (OvCa), to distant organs. They may also promote or inhibit cancer progression and metastasis. Hypoxia, a common phenomenon in malignant… read more here.
Keywords: ovca; hypoxia; expression; ovarian cancer ... See more keywords
Inflammasome expression is higher in ovarian tumors than in normal ovary
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0227081
Abstract: Chronic inflammation fundamentally influences cancer risk and development. A mechanism of chronic inflammation is the formation of inflammasome complexes which results in the sustained secretion of the pro-inflammatory cytokines IL1β and IL18. Inflammasome expression and… read more here.
Keywords: ovarian tumors; ovca; caspase; inflammasome expression ... See more keywords
Microtubule inhibitor, SP-6-27 inhibits angiogenesis and induces apoptosis in ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17549
Abstract: In ovarian cancer (OVCA), treatment failure due to chemo-resistance is a serious challenge. It is therefore critical to identify new therapies that are effective against resistant tumors and have reduced side effects. We recently identified… read more here.
Keywords: ovca; treatment; ovarian cancer; cancer cells ... See more keywords
Silencing of FANCI Promotes DNA Damage and Sensitizes Ovarian Cancer Cells to Carboplatin.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220331091709
Abstract: BACKGROUND Ovarian cancer (OVCA) has unique epigenetic alterations and defects in homologous recombination (HR). Despite initial sensitivity to platinum-based chemotherapy, HR dysfunctional tumors eventually acquire drug resistance. Fanconi anemia (FA) is characterized by bone marrow… read more here.
Keywords: dna damage; expression; fanci; fanci expression ... See more keywords
The Application of an Extracellular Vesicle-Based Biosensor in Early Diagnosis and Prediction of Chemoresponsiveness in Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15092566
Abstract: Ovarian cancer (OVCA) is the most fatal gynecological cancer with late diagnosis and chemoresistance being the main obstacles of treatment success. Since there is no reliable approach to diagnosing patients at an early stage as… read more here.
Keywords: diagnosis; chemoresponsiveness; ovarian cancer; early diagnosis ... See more keywords
MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.66959
Abstract: Objective: To investigate the role of miR-506-3p in ovarian cancer (OvCa) metastasis. Methods: We overexpressed miR-506-3p in OvCa cells, and cell migration and invasion capacities were assessed in vitro using Transwell assays and wound healing… read more here.
Keywords: cancer; metastasis; migration; mir 506 ... See more keywords