LAUSR

Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation.

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0 Published in 2019 at "Toxicology and applied pharmacology"

DOI: 10.1016/j.taap.2019.114714

Abstract: Ovarian toxicity and infertility are major side effects of cancer therapy in young female cancer patients. We and others have previously demonstrated that doxorubicin (DOX), one of the most widely used chemotherapeutic chemicals, has a… read more here.

Keywords: dox induced; overactivation; obliterates mouse; follicle ... See more keywords

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

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1 Published in 2021 at "Blood"

DOI: 10.1182/blood.2020005734

Abstract: Richter's transformation (RT) is an aggressive lymphoma that occurs upon progression from chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic aberrations in the CLL phase involving TP53, CDKN2A, MYC, and NOTCH1; however, a… read more here.

Keywords: aggressive lymphoma; cll; overactivation; transformation ... See more keywords

mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

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1 Published in 2018 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2018.00621

Abstract: Type 2 Diabetes Mellitus (T2DM), a worldwide epidemics, is a progressive disease initially developing an insulin resistant state, with manifest pancreatic beta islet overwork and hyperinsulinemia. As the disease progresses, pancreatic β cells are overwhelmed… read more here.

Keywords: overactivation; mtorc1; type diabetes; diabetes mellitus ... See more keywords

Oxidative Stress-Induced Overactivation of Frog Eggs Triggers Calcium-Dependent Non-Apoptotic Cell Death

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1 Published in 2022 at "Antioxidants"

DOI: 10.3390/antiox11122433

Abstract: Excessive activation of frog eggs (overactivation) is a pathological process that renders eggs unfertilizable. Its physiological inducers are unknown. Previously, oxidative stress was shown to cause time- and dose-dependent overactivation of Xenopus laevis frog eggs.… read more here.

Keywords: frog eggs; overactivation; oxidative stress; stress induced ... See more keywords