Overall success rate of a safe and efficacious drug: Results using six phase 1 designs, each followed by standard phase 2 and 3 designs
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DOI: 10.1016/j.conctc.2018.08.010
Abstract: To evaluate the overall success rate of a new drug, phase 1, 2, and 3 trials were simulated using eight toxicity and two non-decreasing efficacy profiles. Six phase 1 designs including the standard 3 +… read more here.
Keywords: phase; overall success; toxicity; phase designs ... See more keywords