Conjugation of platinum(IV) complexes with chlorambucil to overcome cisplatin resistance via a "joint action" mode toward DNA.
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DOI: 10.1016/j.ejmech.2017.05.056
Abstract: Two platinum(IV) complexes were designed and prepared by conjugation of cisplatin and oxaliplatin units with a DNA-damaging agent, chlorambucil, respectively. By taking a joint action to enhance the damage of DNA, the conjugates displayed potent… read more here.
Keywords: platinum; cisplatin; resistance; joint action ... See more keywords