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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.014
Abstract: A series of forty α-substituted chalcones were synthesized and screened for their antiproliferative activities against HCT116 (colorectal) and HCC1954 (breast) cancer cell lines. Compounds 5a and 5e were found to be the most potent compounds…
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Keywords:
overcome multidrug;
multidrug resistance;
cancer;
cell ... See more keywords
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Published in 2017 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.6b01084
Abstract: Macrocyclic monoacyl lathyrane derivatives bearing a benzoyl moiety were previously found to be strong ABCB1 modulators. To explore the effects of different substituents of the aromatic moiety, 14 new compounds (1.1-1.7, 1.10, and 2.1-2.4) were…
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Keywords:
overcome multidrug;
exploring jolkinol;
jolkinol derivatives;
derivatives overcome ... See more keywords