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Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-020-0596-8
Abstract: Emergence of resistance is a major factor limiting the efficacy of molecularly targeted anticancer drugs. Understanding the specific mutations, or other genetic or cellular changes, that confer drug resistance can help in the development of…
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Keywords:
overcome resistance;
chemical strategies;
resistance;
strategies overcome ... See more keywords
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Published in 2022 at "Nature Chemical Biology"
DOI: 10.1038/s41589-022-00996-7
Abstract: The ability to understand and predict variable responses to therapeutic agents may improve outcomes in patients with cancer. We hypothesized that the basal gene-transcription state of cancer cell lines, coupled with cell viability profiles of…
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Keywords:
drug combinations;
resistance;
combinations overcome;
overcome resistance ... See more keywords
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Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat5025
Abstract: Rotavirus vaccines have oncolytic properties and can overcome resistance to anti–PD-(L)1/CTLA-4 via RIG-I activation upon intratumoral administration. Repurposing a pediatric vaccine Attenuated virus vaccines such as those used to protect against influenza or chickenpox have…
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Keywords:
immune checkpoint;
rotavirus;
rotavirus vaccines;
overcome resistance ... See more keywords
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Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01614-z
Abstract: Venetoclax has been approved by the United States Food and Drug Administration since 2016 as a monotherapy for treating patients with relapsed/refractory chronic lymphocytic leukemia having 17p deletion. It has led to a breakthrough in…
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Keywords:
venetoclax;
overcome resistance;
hematologic malignancies;
resistance ... See more keywords
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Published in 2020 at "ecancermedicalscience"
DOI: 10.3332/ecancer.2020.1148
Abstract: The advent of immunotherapy for cancer represented a paradigm shift in the treatment approach of neoplasia. Immune-checkpoint inhibitors (ICIs) were demonstrated to significantly improve outcomes, including overall survival across several cancer types, with yearly-durable responses.…
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Keywords:
checkpoint blockade;
using checkpoint;
overcome resistance;
resistance ... See more keywords
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Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194783
Abstract: MultiDrug resistance (MDR) is a complex phenomenon responsible for multiple cross-resistance towards structurally unrelated drugs and it characterizes almost 70% of solid and haematological tumours at the diagnosis [...].
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Keywords:
chemotherapy immune;
new strategies;
overcome resistance;
resistance chemotherapy ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010799
Abstract: Improving the prognosis and cure rate of HGOSs (high-grade osteosarcomas) is an absolute need. Immune-based treatment approaches have been increasingly taken into consideration, in particular for metastatic, relapsed and refractory HGOS patients, to ameliorate the…
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Keywords:
resistance immune;
based therapies;
strategies overcome;
overcome resistance ... See more keywords