Chemical strategies to overcome resistance against targeted anticancer therapeutics
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DOI: 10.1038/s41589-020-0596-8
Abstract: Emergence of resistance is a major factor limiting the efficacy of molecularly targeted anticancer drugs. Understanding the specific mutations, or other genetic or cellular changes, that confer drug resistance can help in the development of… read more here.
Keywords: overcome resistance; chemical strategies; resistance; strategies overcome ... See more keywords
Systematic identification of biomarker-driven drug combinations to overcome resistance
Sign Up to like & getrecommendations! Published in 2022 at "Nature Chemical Biology"
DOI: 10.1038/s41589-022-00996-7
Abstract: The ability to understand and predict variable responses to therapeutic agents may improve outcomes in patients with cancer. We hypothesized that the basal gene-transcription state of cancer cell lines, coupled with cell viability profiles of… read more here.
Keywords: drug combinations; resistance; combinations overcome; overcome resistance ... See more keywords
Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat5025
Abstract: Rotavirus vaccines have oncolytic properties and can overcome resistance to anti–PD-(L)1/CTLA-4 via RIG-I activation upon intratumoral administration. Repurposing a pediatric vaccine Attenuated virus vaccines such as those used to protect against influenza or chickenpox have… read more here.
Keywords: immune checkpoint; rotavirus; rotavirus vaccines; overcome resistance ... See more keywords
Combination strategies to overcome resistance to the BCL2 inhibitor venetoclax in hematologic malignancies
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DOI: 10.1186/s12935-020-01614-z
Abstract: Venetoclax has been approved by the United States Food and Drug Administration since 2016 as a monotherapy for treating patients with relapsed/refractory chronic lymphocytic leukemia having 17p deletion. It has led to a breakthrough in… read more here.
Keywords: venetoclax; overcome resistance; hematologic malignancies; resistance ... See more keywords
Combinations using checkpoint blockade to overcome resistance
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DOI: 10.3332/ecancer.2020.1148
Abstract: The advent of immunotherapy for cancer represented a paradigm shift in the treatment approach of neoplasia. Immune-checkpoint inhibitors (ICIs) were demonstrated to significantly improve outcomes, including overall survival across several cancer types, with yearly-durable responses.… read more here.
Keywords: checkpoint blockade; using checkpoint; overcome resistance; resistance ... See more keywords
New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer
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DOI: 10.3390/ijms20194783
Abstract: MultiDrug resistance (MDR) is a complex phenomenon responsible for multiple cross-resistance towards structurally unrelated drugs and it characterizes almost 70% of solid and haematological tumours at the diagnosis [...]. read more here.
Keywords: chemotherapy immune; new strategies; overcome resistance; resistance chemotherapy ... See more keywords
Strategies to Overcome Resistance to Immune-Based Therapies in Osteosarcoma
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DOI: 10.3390/ijms24010799
Abstract: Improving the prognosis and cure rate of HGOSs (high-grade osteosarcomas) is an absolute need. Immune-based treatment approaches have been increasingly taken into consideration, in particular for metastatic, relapsed and refractory HGOS patients, to ameliorate the… read more here.
Keywords: resistance immune; based therapies; strategies overcome; overcome resistance ... See more keywords