Degradation of P-glycoprotein by pristimerin contributes to overcoming ABCB1-mediated chemotherapeutic drug resistance in vitro
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DOI: 10.3892/or.2016.5230
Abstract: ABCB1 (P-glycoprotein, ABCB1/MDR1) is one of the major members of the ABC transporters linked to MDR in cancer cells. In this study, we observed that pristimerin, a natural triterpenoid, potently decreased P-gp in a dose-dependent… read more here.
Keywords: drug resistance; overcoming abcb1; abcb1 mediated; drug ... See more keywords