Overcoming analytical challenges to generate data critical to understanding lipid nanoparticle-delivered modified mRNA biodistribution.
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DOI: 10.4155/bio-2019-0138
Abstract: Aim: Chemically modified mRNA offers a novel approach to treat disease. Due to susceptibility to extracellular nucleases in vivo, dosed modified mRNA therapeutics can benefit from encapsulation within novel delivery systems, such as lipid nanoparticles… read more here.
Keywords: biodistribution; modified mrna; overcoming analytical; analytical challenges ... See more keywords