Overcoming PARP inhibitor resistance in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2022-003698
Abstract: Ovarian cancer (OC) is one of the most lethal tumors in women, mostly diagnosed at advanced stages. Standard of care is based on surgery and platinum-based chemotherapy which provides high rates of response, although most… read more here.
Keywords: ovarian cancer; overcoming parp; cancer overcoming; resistance ... See more keywords
Abstract SY32-03: Overcoming PARP inhibitor resistance through rational combinations in the clinic
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-sy32-03
Abstract: Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA damage response (DDR) and/or increased replication stress. The therapeutic landscape of antitumor agents targeting the DDR has rapidly expanded… read more here.
Keywords: resistance rational; inhibitor resistance; parp inhibitor; overcoming parp ... See more keywords