Overcoming resistance and bypassing checkpoints—possible new therapeutic frontiers in oncology
Sign Up to like & getrecommendations! Published in 2019 at "memo - Magazine of European Medical Oncology"
DOI: 10.1007/s12254-019-0495-4
Abstract: The armamentarium of systemic oncological therapies has constantly increased in recent years and in addition to standard chemotherapy now includes targeted therapies, anti-hormonal therapies, anti-angiogenic therapies and immunotherapy. All these therapeutic approaches have been proven… read more here.
Keywords: checkpoints possible; overcoming resistance; resistance; bypassing checkpoints ... See more keywords
Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.08.021
Abstract: Platinum-based DNA-adducting agents are used extensively in the clinic for cancer chemotherapy. However, the anti-tumor efficacy of these drugs is severely limited by cisplatin resistance, and this can lead to the failure of chemotherapy. One… read more here.
Keywords: vitro vivo; overcoming resistance; cisplatin; resistance ... See more keywords
Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.11.007
Abstract: Irreversible inhibition of transcriptional cyclin-dependent kinases (CDKs) provides a therapeutic strategy for cancers that rely on aberrant transcription; however, lack of understanding of resistance mechanisms to these agents will likely impede their clinical evolution. Here,… read more here.
Keywords: overcoming resistance; covalent; thz series; resistance ... See more keywords
New therapeutic strategies for overcoming resistance and disease persistence in CML
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz345.001
Abstract: Abstract The emergence of resistance to molecular target therapies such as ABL-tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) has become a significant problem despite the remarkable clinical results. The most common cause of… read more here.
Keywords: overcoming resistance; disease; disease persistence; resistance ... See more keywords
Overcoming Resistance: FLT3 Inhibitors Past, Present, Future and the Challenge of Cure
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DOI: 10.3390/cancers14174315
Abstract: Simple Summary Despite the recent approval of some FLT3 inhibitors by drug regulatory agencies, treatment guidelines for FLT3-mutated AML still require allogeneic transplantation as a necessary procedure to treat the disease in first or second… read more here.
Keywords: flt3 inhibitors; present future; resistance; resistance flt3 ... See more keywords
Overcoming resistance to EGFR monotherapy in HNSCC by identification and inhibition of individualized cancer processes
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.64347
Abstract: Therapeutic strategies for advanced head and neck squamous carcinoma (HNSCC) consist of multimodal treatment, including Epidermal Growth Factor Receptor (EGFR) inhibition, immune-checkpoint inhibition, and radio (chemo) therapy. Although over 90% of HNSCC tumors overexpress EGFR,… read more here.
Keywords: inhibition; egfr monotherapy; hnscc tumors; hnscc ... See more keywords