“Improving the performance of Bayesian logistic regression model with overdose control in oncology dose‐finding studies” by Hongtao Zhang, Alan Chiang, and Jixian Wang
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9494
Abstract: In their paper, Zhang et al 1 propose further extensions of the Bayesian Logistic Regression Model (BLRM) with overdose control for dose-escalation studies of a novel drug. These extensions aim to reduce the risk of… read more here.
Keywords: oncology; logistic regression; zhang; overdose control ... See more keywords
Commentary on “Improving the performance of Bayesian logistic regression model with overdose control in oncology dose‐finding studies”
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9496
Abstract: The Bayesian logistic regression model (BLRM) design is a variation of the continuous reassessment method (CRM). Due to the use of an excessively tight escalation with overdose control (EWOC) rule, BLRM has high tendency to… read more here.
Keywords: oncology; logistic regression; overdose control; bayesian logistic ... See more keywords
Rolling dose escalation with overdose control: An efficient and safe phase 1 design.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106436
Abstract: In phase 1 dose escalation studies, dose limiting toxicities (DLTs) are defined as adverse events of concern occurring during a predefined time window after first dosing of patients. Standard dose escalation designs, such as the… read more here.
Keywords: dose escalation; crm; overdose control; escalation ... See more keywords
Hybrid continuous reassessment method with overdose control for safer dose escalation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2170401
Abstract: Phase 1 oncology studies focus on safety of novel treatments and identifying a dose associated with acceptable toxicity level. Various model-based designs have been proposed for guiding dose escalation and estimating maximum tolerated dose in… read more here.
Keywords: continuous reassessment; dose escalation; hybrid continuous; overdose control ... See more keywords
Nonparametric overdose control with late-onset toxicity in phase I clinical trials.
Sign Up to like & getrecommendations! Published in 2017 at "Biostatistics"
DOI: 10.1093/biostatistics/kxw038
Abstract: Under the framework of Bayesian model selection, we propose a nonparametric overdose control (NOC) design for dose finding in phase I clinical trials. Each dose assignment is guided via a feasibility bound, which thereby can… read more here.
Keywords: late onset; nonparametric overdose; toxicity; overdose control ... See more keywords