Reducing overestimation of the treatment effect by interim analysis when designing clinical trials
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DOI: 10.1111/jcpt.12777
Abstract: Several researchers in the statistical and medical communities have noted the overestimation of the treatment effect when a trial is stopped early in the interim analysis for efficacy; however, methods to reduce this overestimation are… read more here.
Keywords: overestimation treatment; interim analysis; overestimation; treatment effect ... See more keywords