UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
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DOI: 10.1016/j.cell.2018.11.024
Abstract: Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 deficiency leads to increased sensitivity to… read more here.
Keywords: tumors ubqln4; homologous recombination; ubqln4 represses; aggressive tumors ... See more keywords