Abstract B44: Role of EGFR/ERBB4 and MAPK signaling in modulating oncogenic potential of ER+ breast cancer cells overexpressing HER3 mutant
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DOI: 10.1158/1557-3125.advbc17-b44
Abstract: We sought to determine if patient-identified mutations in HER3 enhance ER-mediated transformation in human mammary epithelial cells (MCF-7 and T47D). Furthermore, we examined if HER3 mutations confer resistance to ER-specific inhibitors (fulvestrant and 4-hydroxytamoxifen) in… read more here.
Keywords: overexpressing her3; cells overexpressing; her3 mutant; cancer ... See more keywords