PPM1D activity promotes the replication stress caused by cyclin E1 overexpression.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13433
Abstract: Oncogene-induced replication stress has been recognized as a major cause of genome instability in cancer cells. Increased expression of cyclin E1 caused by amplification of the CCNE1 gene is a common cause of replication stress… read more here.
Keywords: replication; overexpression; ppm1d; activity ... See more keywords
β-TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70089
Abstract: Cisplatin is one of the most used anticancer chemotherapy agents; however, over time, patients develop resistance to the treatment, and survival rates drop dramatically. Investigation of tumor cell resistance mechanisms could increase sensitivity and prevent… read more here.
Keywords: dna damage; resistance; cisplatin; trcp ... See more keywords
Overexpression, overproduction, purification, and characterization of rhGH in Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1902
Abstract: Overexpression of insoluble human growth hormone (hGH) in cytoplasm was achieved by E. coli Rosetta‐gami B(DE3) [pET21a (+)‐hGH]). For overexpression of hGH, effects of eight factors including temperature, type and concentration of carbon source, IPTG… read more here.
Keywords: overexpression; overexpression overproduction; rhgh; rhgh production ... See more keywords
Overexpression of blue light receptor AaCRY1 improves artemisinin content in Artemisia annua L.
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DOI: 10.1002/bab.1931
Abstract: Artemisinin, an effective antimalarial compound, is isolated from the medicinal plant Artemisia annua L. However, because of the low content of artemisinin in A. annua, the demand of artemisinin exceeds supply. Previous studies show that… read more here.
Keywords: blue light; overexpression; content; artemisinin content ... See more keywords
Overexpression of the key genes in the biosynthetic pathways of lipid A and peptidoglycan in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2364
Abstract: Gram‐negative bacterium Escherichia coli has a tripartite cell envelope with a cytoplasmic membrane, a peptidoglycan layer, and an asymmetric outer membrane containing lipopolysaccharide in its outer leaflet. The biogenesis of peptidoglycan and lipopolysaccharide shares the… read more here.
Keywords: cell; key genes; escherichia coli; overexpression ... See more keywords
Overexpression of Matriptase‐1 Inhibitor HAI‐1 as an Effective Strategy to Reduce Proteolytic Clipping in Chinese Hamster Ovary Cells
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology Journal"
DOI: 10.1002/biot.70141
Abstract: Proteolytic degradation of recombinant proteins in Chinese hamster ovary (CHO) cells remains a major challenge in biopharmaceutical manufacturing, often reducing product yield and quality. Matriptase‐1, a type II transmembrane serine protease, has been identified as… read more here.
Keywords: hai; hamster ovary; matriptase; overexpression ... See more keywords
Overexpression of OLE1 enhances stress tolerance and constitutively activates the MAPK HOG pathway in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26093
Abstract: OLE1 of Saccharomyces cerevisiae encodes the sole and essential Δ‐9 desaturase catalyzing the conversion of saturated to unsaturated fatty acids. Upon ectopic overexpression of OLE1 in S. cerevisiae, significant increases in the membrane oleic acid… read more here.
Keywords: ole1; overexpression; hog pathway; saccharomyces cerevisiae ... See more keywords
Inexpensive protein overexpression driven by the NarL transcription activator protein
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28071
Abstract: Most Escherichia coli overexpression vectors used for recombinant protein production (RPP) depend on organic inducers, for example, sugars or simple conjugates. However, these can be expensive and, sometimes, chemically unstable. To simplify this and to… read more here.
Keywords: transcription activator; overexpression; activator protein; narl transcription ... See more keywords
MicroRNA‐1 overexpression increases chemosensitivity of non‐small cell lung cancer cells by inhibiting autophagy related 3‐mediated autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10995
Abstract: Non‐small cell lung cancer (NSCLC) is a major type of lung cancer. Drug resistance is a enormous obstacle for cancer treatment. Copious microRNAs (miRNAs) have been demonstrated to be implicated in drug resistance in NSCLC.… read more here.
Keywords: overexpression; nsclc cells; ddp resistant; cancer ... See more keywords
Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.
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DOI: 10.1002/cbin.11716
Abstract: BACKGROUND Currently, the prevention of ischemic diseases such as myocardial infarction associated with ischemia/reperfusion (I/R) injury remains to be a challenge. Thus, this study was designed to explore the effects of tripartite motif protein 11… read more here.
Keywords: overexpression; trim11; apoptosis; dusp1 ... See more keywords
Overexpression of Drosophila NUAK or Constitutively‐Active Formin‐Like Promotes the Formation of Aberrant Myofibrils
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.21999
Abstract: Muscle development and maintenance is central to the normal functioning of animals. Muscle tissues exhibit high levels of activity and require the dynamic turnover of proteins. An actomyosin scaffold functions with additional proteins comprising the… read more here.
Keywords: drosophila nuak; constitutively active; nuak; formin like ... See more keywords