Icariin protects against iron overload‐induced bone loss via suppressing oxidative stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27678
Abstract: Iron overload is common in patients with diseases such as hemoglobinopathies, hereditary hemochromatosis or elderly men and postmenopausal women. This disorder is frequently associated with bone loss and recently has been considered as an independent… read more here.
Keywords: icariin; iron overload; overload induced; bone loss ... See more keywords
Epigallocatechin-3-gallate exerts cardioprotective effects related to energy metabolism in pressure overload-induced cardiac dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2022.109217
Abstract: BACKGROUND To investigate the mechanisms of potential cardioprotective effects of epigallocatechin-3-gallate (EGCG) in pressure overload-induced cardiac dysfunction. METHODS A chronic heart failure model was established using abdominal aortic constriction (AAC) surgery, rats were divided into… read more here.
Keywords: pressure overload; dysfunction; overload induced; metabolism ... See more keywords
Glycine prevents pressure overload induced cardiac hypertrophy mediated by glycine receptor
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.11.008
Abstract: Graphical abstract Figure. No Caption available. Abstract As a major amino acid, glycine has multiple functions in metabolism, growth, immunity, cytoprotection, and survival. The aim of this study was to determine the effects of glycine… read more here.
Keywords: cardiac hypertrophy; pressure overload; glycine receptor; overload induced ... See more keywords
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102088
Abstract: Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid (TCA) cycle that participates in different… read more here.
Keywords: alpha ketoglutarate; akg; pressure overload; dysfunction ... See more keywords
Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20182462
Abstract: Mechanical overload is a risk factor of disc degeneration. It can induce disc degeneration through mediating cell apoptosis. Mechano growth factor (MGF) has been reported to inhibit mechanical overload-induced apoptosis of chondrocytes. The present study… read more here.
Keywords: cell apoptosis; overload; overload induced; mechanical overload ... See more keywords
Circ_nuclear factor I X (circNfix) attenuates pressure overload-induced cardiac hypertrophy via regulating miR-145-5p/ATF3 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1960462
Abstract: Cardiac hypertrophy can cause heart failure. However, the mechanisms underlying the progression of cardiac hypertrophy remain unclear. Emerging evidence suggests that circular RNAs (circRNAs) play a critical role in cardiac hypertrophy. However, the association between… read more here.
Keywords: cardiac hypertrophy; pressure overload; mir 145; circnfix ... See more keywords
Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload–Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001301
Abstract: Abstract: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that mediates the relationship between mitochondrial function and pathological myocardial hypertrophy. However, its underlying mechanisms remain unclear. This study aimed to investigate… read more here.
Keywords: function; hypertrophy; overload induced; trpv1 ... See more keywords
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling
Sign Up to like & getrecommendations! Published in 2020 at "Mediators of Inflammation"
DOI: 10.1155/2020/4121750
Abstract: Ubiquitin-specific protease 2 (USP2) is an important member of the deubiquitination system. GEO dataset revealed that USP2 was downregulated in the hearts under pressure overload. However, the cardiomyocyte-specific function of USP2 in the setting of… read more here.
Keywords: overexpression; induced cardiac; pressure overload; overload induced ... See more keywords
Taurine Ameliorates Iron Overload-Induced Hepatocyte Injury via the Bcl-2/VDAC1-Mediated Mitochondrial Apoptosis Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4135752
Abstract: Iron overload can induce reactive oxygen species (ROS) burst and liver damage. Taurine can reduce ROS production and ameliorate liver injury caused by iron overload; however, the underlying molecular mechanism remains elusive. Herein, L02 cells… read more here.
Keywords: taurine; overload induced; iron overload; bcl ... See more keywords
Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5067544
Abstract: A recent study showed that peroxiredoxins (Prxs) play an important role in the development of pathological cardiac hypertrophy. However, the involvement of Prx5 in cardiac hypertrophy remains unclear. Therefore, this study is aimed at investigating… read more here.
Keywords: overload induced; induced cardiac; hypertrophy; pressure overload ... See more keywords
LncXIST Facilitates Iron Overload and Iron Overload-Induced Islet Beta Cell Injury in Type 2 Diabetes through miR-130a-3p/ALK2 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/6390812
Abstract: Iron overload is directly associated with diabetes mellitus, loss of islet beta cell, and insulin resistance. Likewise, long noncoding RNA (lncRNA) is associated with type 2 diabetes (T2D). Moreover, lncRNAs could be induced by iron… read more here.
Keywords: overload iron; overload induced; iron overload; mir 130a ... See more keywords