Dapagliflozin attenuates cholesterol overloading-induced injury in mice hepatocytes with type 2 diabetes mellitus (T2DM) via eliminating oxidative damages
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DOI: 10.1080/15384101.2022.2031429
Abstract: ABSTRACT Cholesterol overloading-induced damages on hepatocytes cause liver dysfunctions, which further damages cholesterol metabolism and results in visceral fat accumulation in patients with type 2 diabetes mellitus (T2DM). The sodium-glucose cotransporter 2 (SGLT2) inhibitor Dapagliflozin… read more here.
Keywords: diabetes mellitus; cholesterol overloading; overloading induced; type diabetes ... See more keywords
Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries
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DOI: 10.3389/fphar.2021.703847
Abstract: Physiological mechanical stimulation has been shown to promote chondrogenesis, but excessive mechanical loading results in cartilage degradation. Currently, the underlying mechanotransduction pathways in the context of physiological and injurious loading are not fully understood. In… read more here.
Keywords: mechanical overloading; chondrocytes mechanical; overloading induced; protects chondrocytes ... See more keywords