Tumor-Specific Peroxynitrite Overproduction Disrupts Metabolic Homeostasis for Sensitizing Melanoma Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301455
Abstract: Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor microenvironment (TME) for escaping from immunosurveillance. Therefore, interrupting the metabolic adaption of tumor cells might be a promising strategy for TME immunomodulation, favoring immunotherapy. Herein,… read more here.
Keywords: tumor specific; overproduction; melanoma; tumor ... See more keywords
A Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo
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DOI: 10.1002/advs.202001616
Abstract: Abstract Lanthipeptides have extensive therapeutic and industrial applications. However, because many are bactericidal, traditional in vivo platforms are limited in their capacity to discover and mass produce novel lanthipeptides as bacterial organisms are often critical… read more here.
Keywords: overproduction; vivo; cell free; platform ... See more keywords
Pathophysiological significance of hepatokine overproduction in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Diabetology International"
DOI: 10.1007/s13340-018-0368-9
Abstract: Currently, many studies draw attention to novel secretory factors, such as adipokines or myokines, derived from the tissues that were not originally recognized as endocrine organs. The liver may contribute to the onset of various… read more here.
Keywords: overproduction; significance hepatokine; hepatokine overproduction; type diabetes ... See more keywords
Chronic IL-10 overproduction precedes the age-related disruption of microglia-neuron dialogue resulting in impaired hippocampal neurogenesis and spatial memory.
Sign Up to like & getrecommendations! Published in 2022 at "Brain, behavior, and immunity"
DOI: 10.1016/j.bbi.2021.12.026
Abstract: The subgranular zone of the dentate gyrus is an adult neurogenic niche where new neurons are continuously generated. A dramatic hippocampal neurogenesis decline occurs with increasing age, contributing to cognitive deficits. The process of neurogenesis… read more here.
Keywords: age; overproduction; neurogenesis; age related ... See more keywords
Genomic and transcriptional changes in response to pinene tolerance and overproduction in evolved Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2019.05.001
Abstract: α-Pinene is an important monoterpene, which is widely used as a flavoring agent and in fragrances, pharmaceuticals and biofuels. Although an evolved strain Escherichia coli YZFP, which had higher tolerance to pinene and titer, has… read more here.
Keywords: overproduction; tolerance; escherichia coli; tolerance pinene ... See more keywords
Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2020.03.001
Abstract: The lincosamide family antibiotic lincomycin is a widely used antibacterial pharmaceutical generated by Streptomyces lincolnensis, and the high-yield strain B48 produces 2.5 g/L lincomycin, approximately 30-fold as the wild-type strain NRRL 2936. Here, the genome… read more here.
Keywords: overproduction; nrrl 2936; b48; yield strain ... See more keywords
The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2019.11.001
Abstract: Engineering microbes to produce terpenes from renewable feedstock is a promising alternative to traditional production approaches. Generally, terpenes are not readily secreted by microbial cells, and their distribution within cells is usually obscure and often… read more here.
Keywords: overproduction; storage; engineering; subcellular factory ... See more keywords
Flavodiiron protein rescues defects in electron transport around PSI due to overproduction of Rubisco activase in rice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac035
Abstract: The fragility of photosystem I (PSI) was observed in transgenic rice plants overproducing Rubisco activase (RCA) (RCA-ox). This study examined the effects of RCA overproduction on PSI photoinhibition sensitivity in three lines of RCA-ox plants.… read more here.
Keywords: rca; overproduction; electron transport; rubisco activase ... See more keywords
Towards Provably-Secure Analog and Mixed-Signal Locking Against Overproduction
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Emerging Topics in Computing"
DOI: 10.1109/tetc.2020.3025561
Abstract: Similar to digital circuits, analog and mixed-signal (AMS) circuits are also susceptible to supply-chain attacks, such as piracy, overproduction, and Trojan insertion. However, unlike digital circuits, the supply-chain security of AMS circuits is less explored.… read more here.
Keywords: overproduction; ams circuits; mixed signal; analog ... See more keywords
Metabolic engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol
Sign Up to like & getrecommendations! Published in 2023 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.14239
Abstract: The growing need of next generation feedstocks for biotechnology spurs an intensification of research on the utilization of methanol as carbon and energy source for biotechnological processes. In this paper, we introduced the methanol‐based overproduction… read more here.
Keywords: metabolic engineering; riboflavin; overproduction; riboflavin overproduction ... See more keywords
Absence of the KhpA and KhpB (JAG/EloR) RNA‐binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13847
Abstract: Suppressor mutations were isolated that obviate the requirement for essential PBP2b in peripheral elongation of peptidoglycan from the midcells of dividing Streptococcus pneumoniae D39 background cells. One suppressor was in a gene encoding a single… read more here.
Keywords: overproduction; khpb; khpa; d39 ... See more keywords