The different variant allele frequencies of type I/type II mutations and the distinct molecular landscapes in CALR-mutant essential thrombocythaemia and primary myelofibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2107888
Abstract: ABSTRACT Objective Calreticulin (CALR) mutations have been identified as driver mutations in a quarter of patients with essential thrombocythaemia (ET) and primary myelofibrosis (PMF), which are subgroups of myeloproliferative neoplasms (MPNs). A 52-bp deletion (type… read more here.
Keywords: type type; overt pmf; myelofibrosis; calr mutant ... See more keywords
A Predictive Model for Progression to Overt Primary Myelofibrosis in Early/Prefibrotic Primary Myelofibrosis Patients
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DOI: 10.1182/blood-2024-204773
Abstract: Introduction:The 2016 WHO reclassified myelofibrosis into two distinct entities: early/prefibrotic primary myelofibrosis (pre-PMF) and overt primary myelofibrosis (overt-PMF). Approximately 15% of pre-PMF patients progress to overt-PMF during the disease course. Currently, there is limited research… read more here.
Keywords: primary myelofibrosis; pmf; overt pmf; risk ... See more keywords