Generation and characterization of a high‐affinity chimeric anti‐OX40 antibody with potent antitumor activity
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14079
Abstract: OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. OX40 agonist‐based combinations are emerging as promising candidates for novel cancer immunotherapy. Clinical trials have shown that OX40 agonist antibodies… read more here.
Keywords: potent antitumor; ox40 antibody; chimeric anti; anti ox40 ... See more keywords
Neoadjuvant Intratumoral Immunotherapy with TLR9 Activation and Anti-OX40 Antibody Eradicates Metastatic Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-1382
Abstract: The combination of the synthetic TLR9 ligand CpG and agnostic OX40 antibody can trigger systemic anti-tumor immune responses upon co-injection into the tumor microenvironment, eradicating simultaneous untreated sites of metastatic disease. Here we explore the… read more here.
Keywords: immunotherapy; intratumoral immunotherapy; cancer; ox40 antibody ... See more keywords