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   Articles with "ox40 ox40l" as a keyword



Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)

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recommendations! Published in 2019 at "Journal of Immunology Research"

DOI: 10.1155/2019/1780567

Abstract: This study analyzed the expression of membrane OX40 and OX40L (mOX40 and mOX40L) and levels of soluble OX40 and OX40L (sOX40 and sOX40L) in T1D patients to determine their clinical significance. Peripheral blood (PB) was… read more here.

Keywords: mox40 mox40l; ox40 ox40l; sox40 sox40l; form ... See more keywords
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Clinical Significance of OX40 and OX40 Ligand in the Peripheral Blood of Patients with Myasthenia Gravis

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recommendations! Published in 2022 at "Journal of Immunology Research"

DOI: 10.1155/2022/4337399

Abstract: Background A previous study on thymomas in myasthenia gravis (MG) patients indicated that OX40 expression may be upregulated in thymic tissues adjacent to germinal centers (GCs) and thymomas, and OX40 may interact with OX40L in… read more here.

Keywords: ox40 ox40l; ox40; expression; peripheral blood ... See more keywords
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Spatial Mapping and Immunomodulatory Role of the OX40/OX40L Pathway in Human Non–Small Cell Lung Cancer

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recommendations! Published in 2021 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-21-0987

Abstract: Purpose: To evaluate the tissue distribution and clinical significance of OX40 and OX40L in human non–small cell lung cancer (NSCLC). Experimental Design: Using multiplexed quantitative immunofluorescence, we conducted simultaneous and localized measurements of OX40 and… read more here.

Keywords: small cell; human non; cancer; cell ... See more keywords
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Analysis of the OX40/OX40L immunoregulatory axis combined with alternative immune checkpoint molecules in pancreatic ductal adenocarcinoma

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.942154

Abstract: Immune checkpoint modulation has been a vital therapeutic option in many malignancies, and targeting of novel immune checkpoints, including OX40/OX40L costimulatory signaling, is being assessed in clinical trials. However, little is known about the role… read more here.

Keywords: ox40 ox40l; immune checkpoint; ductal adenocarcinoma; ics ox40l ... See more keywords
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Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms222212576

Abstract: Mycosis fungoides (MF) and Sézary syndrome (SS), the most common types of cutaneous T-cell lymphoma (CTCL), are characterized by proliferation of mature CD4+ T-helper cells. Patients with advanced-stage MF and SS have poor prognosis, with… read more here.

Keywords: fungoides zary; zary syndrome; ox40 ox40l; mycosis fungoides ... See more keywords

OX40-OX40L Inhibition for the Treatment of Atopic Dermatitis—Focus on Rocatinlimab and Amlitelimab

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recommendations! Published in 2022 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics14122753

Abstract: Despite the recent emergence of targeted therapeutic options, there are still unmet needs concerning moderate-to-severe atopic dermatitis treatment. This review aims to discuss the OX40-OX40L pathway as a therapeutic target for the treatment of atopic… read more here.

Keywords: atopic dermatitis; ox40 ox40l; treatment; treatment atopic ... See more keywords