PEGylated PAMAM dendrimers loading oxaliplatin with prolonged release and high payload without burst effect.
Sign Up to like & getrecommendations! Published in 2019 at "Biopolymers"
DOI: 10.1002/bip.23272
Abstract: Oxaliplatin (OXA) was coupled to PEGylated polyamidoamine dendrimers of fourth generation (G4-PEG@OXA) in the comparison to PEGylated ones of odd generation (G3.5-PEG@OXA). Proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy were used to confirm the… read more here.
Keywords: peg oxa; oxa; oxaliplatin; pegylated pamam ... See more keywords
Rechallenge with oxaliplatin and peripheral neuropathy in colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2691-8
Abstract: BackgroundOxaliplatin (OXA) is a cornerstone in the treatment of colorectal cancer (CRC). Retreatment with OXA is frequently considered as salvage treatment. OXA-induced neuropathy (OIN) is the most frequent and feared long-term side effect.Patients and methodsCRC… read more here.
Keywords: retreatment; colorectal cancer; cancer; oxa based ... See more keywords
The hypothalamic neuropeptide orexin A- a possible regulator in glucose homeostasis and germ cell kinetics in adult mice testes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.06.021
Abstract: Orexin A (OXA), a hypothalamic neuropeptide, regulates food intake, sleep-wake cycle and energy balance by binding to its receptor (OX1R). Apart from brain, OXA and OX1R are also present in peripheral organs including reproductive tissues.… read more here.
Keywords: glucose homeostasis; oxa ox1r; adult mice; germ cell ... See more keywords
Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Drug Delivery"
DOI: 10.1080/10717544.2021.1914777
Abstract: Abstract Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid… read more here.
Keywords: oha lipid; cd44v6; lipid oxa; colorectal cancer ... See more keywords
Prevalence of a New Variant OXA-204 and OXA-48 Carbapenemases Plasmids Encoded in Klebsiella pneumoniae Clinical Isolates in Tunisia
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Drug Resistance"
DOI: 10.1089/mdr.2016.0236
Abstract: Carbapenemase-producing Klebsiella pneumoniae strains have emerged as a major problem for healthcare systems. The aim of this study was to determine the role and diversity of plasmids harboring carbapenemases encoding genes from a collection of… read more here.
Keywords: pneumoniae; klebsiella pneumoniae; new variant; prevalence new ... See more keywords
Colonization with Enterobacteriaceae-Producing ESBLs, AmpCs, and OXA-48 in Wild Avian Species, Spain 2015-2016.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0004
Abstract: Antibiotic resistance is a global threat of complex and changeable epidemiology. The role of wild birds in the dissemination of antibacterial resistance might be underestimated. We studied the cloacal colonization by cefotaxime-resistant Enterobacteriaceae in 668… read more here.
Keywords: cefotaxime resistant; colonization enterobacteriaceae; colonization; wild birds ... See more keywords
PCR Detection of Oxacillinases in Bacteria.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial drug resistance"
DOI: 10.1089/mdr.2019.0330
Abstract: Oxacillinases (OXA) have been mostly described in Enterobacteriaceae, Acinetobacter, and Pseudomonas species. Recent years have witnessed an increased prevalence of intrinsic and/or acquired β-lactamase-producing Acinetobacter in food-producing animals. This study was conducted to assess the… read more here.
Keywords: oxacillinases bacteria; presence; pcr detection; detection oxacillinases ... See more keywords
Deciphering the role of residues in the loops nearing the active site of OXA-58 in imparting beta-lactamase activity.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001203
Abstract: The existence of OXA-58 carbapenemase alone or in combination with other beta-lactam resistance factors poses significant beta-lactam resistance. The exact mechanism of action of OXA type beta-lactamases is debatable due to the involvement of multiple… read more here.
Keywords: role residues; oxa; activity; active site ... See more keywords
Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 β-Lactamase
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01202-19
Abstract: Carbapenem-hydrolyzing class D carbapenemases (CHDLs) are enzymes that produce resistance to the last-resort carbapenem antibiotics, severely compromising the available therapeutic options for the treatment of life-threatening infections. A broad variety of CHDLs, including OXA-23, OXA-24/40,… read more here.
Keywords: baumannii; mechanism carbapenemase; oxa; carbapenemase activity ... See more keywords
An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00315-22
Abstract: The transmission of genes coding for resistance factors from environmental to nosocomial strains is a major component in the development of bacterial resistance toward antibiotics. Our survey of class D beta-lactamase genes in genomic databases… read more here.
Keywords: class beta; beta; beta lactamases; oxa ... See more keywords
Computational exploration of molecular flexibility and interaction of meropenem analogs with the active site of oxacillinase-23 in Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1090630
Abstract: Background: Carbapenem-resistant Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections and is one of the biggest global threats according to the World Health Organization (WHO), particularly causing substantial morbidity and mortality. Objectives: This… read more here.
Keywords: oxa; acinetobacter baumannii; energy; meropenem analogs ... See more keywords