Palladium-Catalyzed Ring Opening of Vinyl Oxetanes Enables Asymmetric Dearomative [6 + 2] Cycloaddition of 3-Nitroindoles to Access Indoline-Fused Oxa-Eight-Membered Rings.
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DOI: 10.1021/acs.orglett.5c03560
Abstract: We present a catalyst system consisting of a chiral (R)-xyl-BINAP ligand and PdCl2, which enables the ring opening of vinyl oxetanes to drive asymmetric dearomatization of 3-nitroindoles for the enantioselective [6 + 2] cycloaddition, leading… read more here.
Keywords: vinyl oxetanes; oxa eight; indoline fused; ring opening ... See more keywords